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The CST Complex Mediates End Protection at Double-Strand Breaks and Promotes PARP Inhibitor Sensitivity in BRCA1-Deficient Cells.
Barazas, Marco; Annunziato, Stefano; Pettitt, Stephen J; de Krijger, Inge; Ghezraoui, Hind; Roobol, Stefan J; Lutz, Catrin; Frankum, Jessica; Song, Fei Fei; Brough, Rachel; Evers, Bastiaan; Gogola, Ewa; Bhin, Jinhyuk; van de Ven, Marieke; van Gent, Dik C; Jacobs, Jacqueline J L; Chapman, Ross; Lord, Christopher J; Jonkers, Jos; Rottenberg, Sven.
Affiliation
  • Barazas M; Division of Molecular Pathology, Oncode Institute, the Netherlands Cancer Institute, 1066CX Amsterdam, the Netherlands.
  • Annunziato S; Division of Molecular Pathology, Oncode Institute, the Netherlands Cancer Institute, 1066CX Amsterdam, the Netherlands.
  • Pettitt SJ; The CRUK Gene Function Laboratory and Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London SW3 6JB, UK.
  • de Krijger I; Division of Oncogenomics, the Netherlands Cancer Institute, 1066CX Amsterdam, the Netherlands.
  • Ghezraoui H; Genome Integrity Laboratory, Wellcome Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
  • Roobol SJ; Department of Genetics, Erasmus University Medical Center, Rotterdam, the Netherlands; Department of Radiology and Nuclear Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands.
  • Lutz C; Division of Molecular Pathology, Oncode Institute, the Netherlands Cancer Institute, 1066CX Amsterdam, the Netherlands.
  • Frankum J; The CRUK Gene Function Laboratory and Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London SW3 6JB, UK.
  • Song FF; The CRUK Gene Function Laboratory and Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London SW3 6JB, UK.
  • Brough R; The CRUK Gene Function Laboratory and Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London SW3 6JB, UK.
  • Evers B; Division of Molecular Carcinogenesis, the Netherlands Cancer Institute, 1066CX Amsterdam, the Netherlands.
  • Gogola E; Division of Molecular Pathology, Oncode Institute, the Netherlands Cancer Institute, 1066CX Amsterdam, the Netherlands.
  • Bhin J; Division of Molecular Pathology, Oncode Institute, the Netherlands Cancer Institute, 1066CX Amsterdam, the Netherlands; Division of Molecular Carcinogenesis, the Netherlands Cancer Institute, 1066CX Amsterdam, the Netherlands.
  • van de Ven M; Division of Molecular Pathology, Oncode Institute, the Netherlands Cancer Institute, 1066CX Amsterdam, the Netherlands; Mouse Clinic for Cancer and Aging Research (MCCA), Preclinical Intervention Unit, the Netherlands Cancer Institute, 1066CX Amsterdam, the Netherlands.
  • van Gent DC; Department of Genetics, Erasmus University Medical Center, Rotterdam, the Netherlands.
  • Jacobs JJL; Division of Oncogenomics, the Netherlands Cancer Institute, 1066CX Amsterdam, the Netherlands.
  • Chapman R; Genome Integrity Laboratory, Wellcome Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
  • Lord CJ; The CRUK Gene Function Laboratory and Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London SW3 6JB, UK.
  • Jonkers J; Division of Molecular Pathology, Oncode Institute, the Netherlands Cancer Institute, 1066CX Amsterdam, the Netherlands. Electronic address: j.jonkers@nki.nl.
  • Rottenberg S; Division of Molecular Pathology, Oncode Institute, the Netherlands Cancer Institute, 1066CX Amsterdam, the Netherlands; Institute of Animal Pathology, Vetsuisse Faculty, University of Bern, Bern, Switzerland. Electronic address: sven.rottenberg@vetsuisse.unibe.ch.
Cell Rep ; 23(7): 2107-2118, 2018 05 15.
Article in En | MEDLINE | ID: mdl-29768208
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Full text: 1 Database: MEDLINE Main subject: BRCA1 Protein / Multiprotein Complexes / DNA Breaks, Double-Stranded / Poly(ADP-ribose) Polymerase Inhibitors Type of study: Diagnostic_studies / Prognostic_studies Limits: Animals Language: En Journal: Cell Rep Year: 2018 Type: Article Affiliation country: Netherlands
Fulltext
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Full text: 1 Database: MEDLINE Main subject: BRCA1 Protein / Multiprotein Complexes / DNA Breaks, Double-Stranded / Poly(ADP-ribose) Polymerase Inhibitors Type of study: Diagnostic_studies / Prognostic_studies Limits: Animals Language: En Journal: Cell Rep Year: 2018 Type: Article Affiliation country: Netherlands