Tumor-related epilepsy: epidemiology, pathogenesis and management.
J Neurooncol
; 139(1): 13-21, 2018 Aug.
Article
in En
| MEDLINE
| ID: mdl-29797181
ABSTRACT
INTRODUCTION:
Seizure is a common comorbidity in patients with brain tumor. It may be the presenting symptom or develop after the tumor diagnosis. The underlying pathophysiology of brain tumor-related epilepsy remains poorly understood.METHODS:
A comprehensive literature review of Pubmed English articles from 1980-2017 was performed to summarize current knowledge and treatment options of brain tumor-related epilepsy.RESULTS:
Multiple factors have been found to contribute to tumor-related epilepsy, including tumor type, speed of tumor growth, location, and tumor burden. The underlying pathogenesis of epilepsy is not clear but perturbations in the peri-tumoral regions, both structural and cellular communications, have been implicated.CONCLUSIONS:
Surgical and medical treatments of tumor-related epilepsy remain challenging as additional factors such as the extent of surgical resection, interactions with tumor-related oncological treatments and anti-epileptic medication related side effects need to be considered.Key words
Full text:
1
Database:
MEDLINE
Main subject:
Brain Neoplasms
/
Epilepsy
Type of study:
Etiology_studies
/
Screening_studies
Limits:
Humans
Language:
En
Journal:
J Neurooncol
Year:
2018
Type:
Article
Affiliation country:
United States