Harnessing Tumor Evolution to Circumvent Resistance.
Trends Genet
; 34(8): 639-651, 2018 08.
Article
in En
| MEDLINE
| ID: mdl-29903534
ABSTRACT
High-throughput sequencing can be used to measure changes in tumor composition across space and time. Specifically, comparisons of pre- and post-treatment samples can reveal the underlying clonal dynamics and resistance mechanisms. Here, we discuss evidence for distinct modes of tumor evolution and their implications for therapeutic strategies. In addition, we consider the utility of spatial tissue sampling schemes, single-cell analysis, and circulating tumor DNA to track tumor evolution and the emergence of resistance, as well as approaches that seek to forestall resistance by targeting tumor evolution. Ultimately, characterization of the (epi)genomic, transcriptomic, and phenotypic changes that occur during tumor progression coupled with computational and mathematical modeling of tumor evolutionary dynamics may inform personalized treatment strategies.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Cell Transformation, Neoplastic
/
Models, Biological
/
Neoplasms
Limits:
Animals
/
Humans
Language:
En
Journal:
Trends Genet
Journal subject:
GENETICA
Year:
2018
Type:
Article