Rapid Electrical Stimulation Increased Cardiac Apoptosis Through Disturbance of Calcium Homeostasis and Mitochondrial Dysfunction in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes.

Geng, Le; Wang, Zidun; Cui, Chang; Zhu, Yue; Shi, Jiaojiao; Wang, Jiaxian; Chen, Minglong

Geng, Le; Wang, Zidun; Cui, Chang; Zhu, Yue; Shi, Jiaojiao; Wang, Jiaxian; Chen, Minglong.

Cell Physiol Biochem ; 47(3): 1167-1180, 2018.

Article in En | MEDLINE | ID: mdl-29913448

Subject(s)

Calcium Signaling; Calcium/metabolism; Electric Stimulation Therapy/adverse effects; Induced Pluripotent Stem Cells/metabolism; Mitochondria, Heart/metabolism; Myocytes, Cardiac/metabolism; Heart Failure/metabolism; Heart Failure/pathology; Heart Failure/therapy; Humans; Induced Pluripotent Stem Cells/pathology; Mitochondria, Heart/pathology; Myocytes, Cardiac/pathology; Tachycardia/metabolism; Tachycardia/pathology; Tachycardia/therapy

Key words

Apoptosis; CaMKII; Calcium homeostasis; HiPSC-CMs; Mitochondria; Rapid electrical stimulation

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Full text: 1 Database: MEDLINE Main subject: Electric Stimulation Therapy / Calcium / Calcium Signaling / Myocytes, Cardiac / Induced Pluripotent Stem Cells / Mitochondria, Heart Limits: Humans Language: En Journal: Cell Physiol Biochem Journal subject: BIOQUIMICA / FARMACOLOGIA Year: 2018 Type: Article

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