The potential of imaging tools as correlates of infection and disease for new TB vaccine development.
Semin Immunol
; 39: 73-80, 2018 10.
Article
in En
| MEDLINE
| ID: mdl-29914653
ABSTRACT
The development of an improved vaccine to stimulate an effective response against Mycobacterium tuberculosis (MTB) infection and disease will be a major breakthrough in the fight against TB. A lack of tools to adequately track the progression or resolution of events in TB pathogenesis that occur at bacterial loads below the threshold for culture in human samples seriously hampers vaccine development and evaluation. In this review we discuss recent studies that use new imaging applications, modalities and analysis techniques to provide insight into the dynamic processes of MTB infection and disease that are challenging to monitor. These include early infection, the spectrum of latency and subclinical disease, the paucibacillary state induced by treatment, and events leading to recurrence, including relapse.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Tuberculosis, Pulmonary
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Fluorodeoxyglucose F18
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Tuberculosis Vaccines
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Latent Tuberculosis
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Molecular Imaging
Limits:
Animals
/
Humans
Language:
En
Journal:
Semin Immunol
Journal subject:
ALERGIA E IMUNOLOGIA
Year:
2018
Type:
Article
Affiliation country:
South Africa