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The potential of imaging tools as correlates of infection and disease for new TB vaccine development.
Malherbe, Stephanus T; Kleynhans, Léanie; Walzl, Gerhard.
Affiliation
  • Malherbe ST; DST/NRF Centre of Excellence for Biomedical Tuberculosis Research, South African Medical Research Council Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
  • Kleynhans L; DST/NRF Centre of Excellence for Biomedical Tuberculosis Research, South African Medical Research Council Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
  • Walzl G; DST/NRF Centre of Excellence for Biomedical Tuberculosis Research, South African Medical Research Council Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa. Electronic address: gwalzl@sun.ac.za.
Semin Immunol ; 39: 73-80, 2018 10.
Article in En | MEDLINE | ID: mdl-29914653
ABSTRACT
The development of an improved vaccine to stimulate an effective response against Mycobacterium tuberculosis (MTB) infection and disease will be a major breakthrough in the fight against TB. A lack of tools to adequately track the progression or resolution of events in TB pathogenesis that occur at bacterial loads below the threshold for culture in human samples seriously hampers vaccine development and evaluation. In this review we discuss recent studies that use new imaging applications, modalities and analysis techniques to provide insight into the dynamic processes of MTB infection and disease that are challenging to monitor. These include early infection, the spectrum of latency and subclinical disease, the paucibacillary state induced by treatment, and events leading to recurrence, including relapse.
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Full text: 1 Database: MEDLINE Main subject: Tuberculosis, Pulmonary / Fluorodeoxyglucose F18 / Tuberculosis Vaccines / Latent Tuberculosis / Molecular Imaging Limits: Animals / Humans Language: En Journal: Semin Immunol Journal subject: ALERGIA E IMUNOLOGIA Year: 2018 Type: Article Affiliation country: South Africa

Full text: 1 Database: MEDLINE Main subject: Tuberculosis, Pulmonary / Fluorodeoxyglucose F18 / Tuberculosis Vaccines / Latent Tuberculosis / Molecular Imaging Limits: Animals / Humans Language: En Journal: Semin Immunol Journal subject: ALERGIA E IMUNOLOGIA Year: 2018 Type: Article Affiliation country: South Africa