Depletion of A-type lamins and Lap2&#945; reduces 53BP1 accumulation at UV-induced DNA lesions and Lap2&#945; protein is responsible for compactness of irradiated chromatin.

Bártová, Eva; Legartová, Sona; Krejcí, Jana; Reznícková, Petra; Kovaríková, Alena Svobodová; Suchánková, Jana; Fedr, Radek; Smirnov, Evgeny; Hornácek, Matús; Raska, Ivan

Depletion of A-type lamins and Lap2α reduces 53BP1 accumulation at UV-induced DNA lesions and Lap2α protein is responsible for compactness of irradiated chromatin.

Bártová, Eva; Legartová, Sona; Krejcí, Jana; Reznícková, Petra; Kovaríková, Alena Svobodová; Suchánková, Jana; Fedr, Radek; Smirnov, Evgeny; Hornácek, Matús; Raska, Ivan.

Affiliation

Bártová E; Institute of Biophysics of the Czech Academy of Sciences, Brno, Czech Republic.
Legartová S; Institute of Biophysics of the Czech Academy of Sciences, Brno, Czech Republic.
Krejcí J; Institute of Biophysics of the Czech Academy of Sciences, Brno, Czech Republic.
Reznícková P; Institute of Biophysics of the Czech Academy of Sciences, Brno, Czech Republic.
Kovaríková AS; Institute of Biophysics of the Czech Academy of Sciences, Brno, Czech Republic.
Suchánková J; Institute of Biophysics of the Czech Academy of Sciences, Brno, Czech Republic.
Fedr R; Institute of Biophysics of the Czech Academy of Sciences, Brno, Czech Republic.
Smirnov E; Institute of Biology and Medical Genetics, First Faculty of Medicine, Charles University in Prague, Prague, Czech Republic.
Hornácek M; Institute of Biology and Medical Genetics, First Faculty of Medicine, Charles University in Prague, Prague, Czech Republic.
Raska I; Institute of Biology and Medical Genetics, First Faculty of Medicine, Charles University in Prague, Prague, Czech Republic.

J Cell Biochem ; 119(10): 8146-8162, 2018 11.

Article in En | MEDLINE | ID: mdl-29923310

Subject(s)

Chromatin/radiation effects; DNA Repair; DNA-Binding Proteins/genetics; Fibroblasts/radiation effects; Lamin Type A/genetics; Membrane Proteins/genetics; Tumor Suppressor p53-Binding Protein 1/genetics; Animals; Cell Line, Transformed; Chromatin/chemistry; Chromatin/ultrastructure; DNA Damage; DNA-Binding Proteins/deficiency; Embryo, Mammalian; Fibroblasts/cytology; Fibroblasts/metabolism; Fluorescence Recovery After Photobleaching; Gamma Rays; Gene Expression Regulation; Genes, Reporter; Histones/genetics; Histones/metabolism; Lamin Type A/deficiency; Luminescent Proteins/genetics; Luminescent Proteins/metabolism; Membrane Proteins/deficiency; Mice; Recombinant Fusion Proteins/genetics; Recombinant Fusion Proteins/metabolism; Signal Transduction; Tumor Suppressor p53-Binding Protein 1/metabolism; Ultraviolet Rays; Red Fluorescent Protein

Key words

DNA damage; Lap2α; confocal microscopy; epigenetics; immunohistochemistry; lamins

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Full text: 1 Database: MEDLINE Main subject: Chromatin / Lamin Type A / DNA-Binding Proteins / DNA Repair / Fibroblasts / Tumor Suppressor p53-Binding Protein 1 / Membrane Proteins Limits: Animals Language: En Journal: J Cell Biochem Year: 2018 Type: Article Affiliation country: Czech Republic

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