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Durable response in a woman with recurrent low-grade endometrioid endometrial cancer and a germline BRCA2 mutation treated with a PARP inhibitor.
Gockley, Allison A; Kolin, David L; Awtrey, Christopher S; Lindeman, Neal I; Matulonis, Ursula A; Konstantinopoulos, Panagiotis A.
Affiliation
  • Gockley AA; Division of Gynecologic Oncology, Department of Obstetrics, Gynecology and Reproductive Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
  • Kolin DL; Division of Women's and Perinatal Pathology, Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
  • Awtrey CS; Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Beth-Israel Deaconess Medical Center, Boston, MA 02130, USA.
  • Lindeman NI; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
  • Matulonis UA; Division of Gynecologic Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
  • Konstantinopoulos PA; Division of Gynecologic Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA. Electronic address: Panagiotis_konstantinopouos@dfci.harvard.edu.
Gynecol Oncol ; 150(2): 219-226, 2018 08.
Article in En | MEDLINE | ID: mdl-29937315
ABSTRACT
A 42-year-old woman with a germline BRCA2 mutation and recurrent low-grade endometrioid endometrial adenocarcinoma experienced clinical and radiographic response to the poly (ADP ribose) polymerase (PARP) inhibitor, olaparib. Molecular and treatment factors are discussed.
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Full text: 1 Database: MEDLINE Main subject: Endometrial Neoplasms / Germ-Line Mutation / Carcinoma, Endometrioid / BRCA2 Protein / Poly(ADP-ribose) Polymerase Inhibitors Limits: Adult / Female / Humans Language: En Journal: Gynecol Oncol Year: 2018 Type: Article Affiliation country: United States
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Full text: 1 Database: MEDLINE Main subject: Endometrial Neoplasms / Germ-Line Mutation / Carcinoma, Endometrioid / BRCA2 Protein / Poly(ADP-ribose) Polymerase Inhibitors Limits: Adult / Female / Humans Language: En Journal: Gynecol Oncol Year: 2018 Type: Article Affiliation country: United States