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0.01% Hypochlorous Acid as an Alternative Skin Antiseptic: An In Vitro Comparison.
Anagnostopoulos, Apostolos G; Rong, Andrew; Miller, Darlene; Tran, Ann Q; Head, Trajen; Lee, Michael C; Lee, Wendy W.
Affiliation
  • Anagnostopoulos AG; Department of Ophthalmology, Oculoplastic & Reconstructive Surgery, Bascom Palmer Eye Institute, Miami, Florida.
  • Rong A; Department of Ophthalmology, Oculoplastic & Reconstructive Surgery, Bascom Palmer Eye Institute, Miami, Florida.
  • Miller D; Department of Microbiology, Bascom Palmer Eye Institute, Miami, Florida.
  • Tran AQ; Department of Ophthalmology, Oculoplastic & Reconstructive Surgery, Bascom Palmer Eye Institute, Miami, Florida.
  • Head T; Department of Biochemistry and Molecular Biology, University of Miami, Miami, Florida.
  • Lee MC; Westminster High School, Palmetto Bay, Florida.
  • Lee WW; Department of Ophthalmology, Oculoplastic & Reconstructive Surgery, Bascom Palmer Eye Institute, Miami, Florida.
Dermatol Surg ; 44(12): 1489-1493, 2018 12.
Article in En | MEDLINE | ID: mdl-29985866
ABSTRACT

OBJECTIVE:

Compare the in vitro efficacy of hypochlorous acid 0.01% (HA), povidone iodine 5% (PI), chlorhexidine gluconate 4% (CHG), and isopropyl alcohol 70% (IPA) against common skin microorganisms. MATERIALS AND

METHODS:

Time-kill studies were conducted against methicillin-susceptible Staphylococcus aureus (MSSA) and Staphylococcus epidermidis (MSSE), methicillin-resistant S. aureus (MRSA) and S. epidermidis (MRSE), Candida albicans, Corynebacterium species (striatum and amycolatum), Propionibacterium acnes, Pseudomonas aeruginosa, Streptococcus pyogenes, Staphylococcus capitis, and Staphylococcus xylosus.

RESULTS:

Methicillin-resistant S. aureus Bactericidal effect was immediate for HA and IPA. For PI and CHG, the effect occurred at 1 and 10 minutes, respectively. Methicillin-resistant S. epidermidis Hypochlorous acid, IPA, and PI had immediate bactericidal effects, whereas CHG required 1 minute. Methicillin-susceptible Staphylococcus aureus All agents had bactericidal effects at 1 minute. C. species, S. pyogenes, P. aeruginosa, and P. acnes All antiseptics demonstrated immediate bactericidal effects. Methicillin-susceptible Staphylococcus epidermidis and S. capitis Hypochlorous acid and IPA had immediate effect, whereas PI and CHG required 1 minute. C. albicans Hypochlorous acid, IPA, and PI were immediately bactericidal, whereas CHG required 1 minute. S. xylosus Hypochlorous acid and CHG were immediately bactericidal, whereas IPA and PI required 1 and 2 minutes, respectively.

CONCLUSION:

In vitro studies of HA 0.01% were observed to have equal or more efficacious antiseptic properties compared with IPA, CHG, and PI. Future studies will be needed to investigate its role in periocular use.
Subject(s)

Full text: 1 Database: MEDLINE Main subject: Povidone-Iodine / Chlorhexidine / Hypochlorous Acid / 2-Propanol / Anti-Infective Agents, Local Language: En Journal: Dermatol Surg Journal subject: DERMATOLOGIA Year: 2018 Type: Article

Full text: 1 Database: MEDLINE Main subject: Povidone-Iodine / Chlorhexidine / Hypochlorous Acid / 2-Propanol / Anti-Infective Agents, Local Language: En Journal: Dermatol Surg Journal subject: DERMATOLOGIA Year: 2018 Type: Article