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Pharmacology and Therapeutic Potential of the 5-HT7 Receptor.
Blattner, Kevin M; Canney, Daniel J; Pippin, Douglas A; Blass, Benjamin E.
Affiliation
  • Blattner KM; Temple University School of Pharmacy, Department of Pharmaceutical Sciences, Moulder Center for Drug Discovery Research , 3307 North Broad Street , Philadelphia , Pennsylvania 19140 , United States.
  • Canney DJ; Temple University School of Pharmacy, Department of Pharmaceutical Sciences, Moulder Center for Drug Discovery Research , 3307 North Broad Street , Philadelphia , Pennsylvania 19140 , United States.
  • Pippin DA; Praeventix, LLC , 665 Stockton Drive, Suite 200H , Exton , Pennsylvania 19341 , United States.
  • Blass BE; Temple University School of Pharmacy, Department of Pharmaceutical Sciences, Moulder Center for Drug Discovery Research , 3307 North Broad Street , Philadelphia , Pennsylvania 19140 , United States.
ACS Chem Neurosci ; 10(1): 89-119, 2019 01 16.
Article in En | MEDLINE | ID: mdl-30020772
ABSTRACT
It is well-documented that serotonin (5-HT) exerts its pharmacological effects through a series of 5-HT receptors. The most recently identified member of this family, 5-HT7, was first identified in 1993. Over the course of the last 25 years, this receptor has been the subject of intense investigation, and it has been demonstrated that 5-HT7 plays an important role in a wide range of pharmacological processes. As a result of these findings, modulation of 5-HT7 activity has been the focus of numerous drug discovery and development programs. This review provides an overview of the roles of 5-HT7 in normal physiology and the therapeutic potential of this interesting drug target.
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Full text: 1 Database: MEDLINE Main subject: Serotonin Antagonists / Receptors, Serotonin / Serotonin Receptor Agonists / Drug Discovery Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: ACS Chem Neurosci Year: 2019 Type: Article Affiliation country: United States
Fulltext
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Full text: 1 Database: MEDLINE Main subject: Serotonin Antagonists / Receptors, Serotonin / Serotonin Receptor Agonists / Drug Discovery Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: ACS Chem Neurosci Year: 2019 Type: Article Affiliation country: United States