The Ras-like GTPase Rem2 is a potent inhibitor of calcium/calmodulin-dependent kinase II activity.

Royer, Leandro; Herzog, Josiah J; Kenny, Katelyn; Tzvetkova, Boriana; Cochrane, Jesse C; Marr, Michael T; Paradis, Suzanne

Royer, Leandro; Herzog, Josiah J; Kenny, Katelyn; Tzvetkova, Boriana; Cochrane, Jesse C; Marr, Michael T; Paradis, Suzanne.

Affiliation

Royer L; From the Department of Biology.
Herzog JJ; From the Department of Biology.
Kenny K; From the Department of Biology.
Tzvetkova B; From the Department of Biology.
Cochrane JC; Department of Molecular Biology and Genetics, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114.
Marr MT; From the Department of Biology, mmarr@brandeis.edu.
Paradis S; Rosenstiel Basic Medical Sciences Research Center.

J Biol Chem ; 293(38): 14798-14811, 2018 09 21.

Article in En | MEDLINE | ID: mdl-30072381

Subject(s)

Calcium-Calmodulin-Dependent Protein Kinase Type 2/antagonists & inhibitors; Monomeric GTP-Binding Proteins/physiology; Animals; Calcium/metabolism; Cells, Cultured; HEK293 Cells; Hippocampus/cytology; Hippocampus/enzymology; Hippocampus/metabolism; Homeostasis; Humans; Learning; Long-Term Potentiation; Memory; Mice; Monomeric GTP-Binding Proteins/chemistry; Neuronal Plasticity; Neurons/metabolism; Phosphorylation; Substrate Specificity

Key words

Ca2+/calmodulin-dependent protein kinase II (CaMKII); GTPase; RGK family; Rem2; autophosphorylation; calcium; inhibitor; phosphorylation

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Full text: 1 Database: MEDLINE Main subject: Monomeric GTP-Binding Proteins / Calcium-Calmodulin-Dependent Protein Kinase Type 2 Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: J Biol Chem Year: 2018 Type: Article

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