Role of B-cell receptors for B-cell development and antigen-induced differentiation.
F1000Res
; 7: 429, 2018.
Article
in En
| MEDLINE
| ID: mdl-30090624
ABSTRACT
B-cell development is characterized by a number of tightly regulated selection processes. Signals through the B-cell receptor (BCR) guide and are required for B-cell maturation, survival, and fate decision. Here, we review the role of the BCR during B-cell development, leading to the emergence of B1, marginal zone, and peripheral follicular B cells. Furthermore, we discuss BCR-derived signals on activated B cells that lead to germinal center and plasma cell differentiation.
Full text:
1
Database:
MEDLINE
Language:
En
Journal:
F1000Res
Year:
2018
Type:
Article
Affiliation country:
United kingdom