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Bifunctional Au@Bi2 Se3 Core-Shell Nanoparticle for Synergetic Therapy by SERS-Traceable AntagomiR Delivery and Photothermal Treatment.
Mohammadniaei, Mohsen; Lee, Taek; Bharate, Bapurao G; Yoon, Jinho; Choi, Hye Kyu; Park, Soo-Jeong; Kim, Junghoon; Kim, Jungho; Choi, Jeong-Woo.
Affiliation
  • Mohammadniaei M; Department of Chemical and Biomolecular Engineering, Sogang University, 35 Baekbeom-ro (Sinsu-dong), Mapo-gu, Seoul, 121-742, Republic of Korea.
  • Lee T; Department of Chemical Engineering, Kwangwoon University, 20 Kwangwoon-ro, Nowon-gu, Seoul, 01897, Republic of Korea.
  • Bharate BG; Department of Chemical and Biomolecular Engineering, Sogang University, 35 Baekbeom-ro (Sinsu-dong), Mapo-gu, Seoul, 121-742, Republic of Korea.
  • Yoon J; Department of Chemical and Biomolecular Engineering, Sogang University, 35 Baekbeom-ro (Sinsu-dong), Mapo-gu, Seoul, 121-742, Republic of Korea.
  • Choi HK; Department of Chemical and Biomolecular Engineering, Sogang University, 35 Baekbeom-ro (Sinsu-dong), Mapo-gu, Seoul, 121-742, Republic of Korea.
  • Park SJ; Research Center for Disease Biophysics of Sogang-Harvard, Sogang University, 35 Baekbeom-ro (Sinsu-dong), Mapo-gu, Seoul, 121-742, Republic of Korea.
  • Kim J; Department of Life Science, Sogang University, 35 Baekbeom-ro (Sinsu-dong), Mapo-gu, Seoul, 121-742, Republic of Korea.
  • Kim J; Department of Life Science, Sogang University, 35 Baekbeom-ro (Sinsu-dong), Mapo-gu, Seoul, 121-742, Republic of Korea.
  • Choi JW; Department of Chemical and Biomolecular Engineering, Sogang University, 35 Baekbeom-ro (Sinsu-dong), Mapo-gu, Seoul, 121-742, Republic of Korea.
Small ; 14(38): e1802934, 2018 09.
Article in En | MEDLINE | ID: mdl-30141567
ABSTRACT
For the first time, topological insulator bismuth selenide nanoparticles (Bi2 Se3 NP) are core-shelled with gold (Au@Bi2 Se3 ) i) to represent considerably small-sized (11 nm) plasmonic nanoparticles, enabling accurate bioimaging in the near-infrared region; ii) to substantially improve Bi2 Se3 biocompatibility, iii) water dispersibility, and iv) surface functionalization capability through straightforward gold-thiol interaction. The Au@Bi2 Se3 is subsequently functionalized for v) effective targeting of SH-SY5Y cancer cells, vi) disrupting the endosome/lysosome membrane, vii) traceable delivery of antagomiR-152 and further synergetic oncomiR knockdown and photothermal therapy (PTT). Unprecedentedly, it is observed that the Au shell thickness has a significant impact on evoking the exotic plasmonic features of Bi2 Se3 . The Au@Bi2 Se3 possesses a high photothermal conversion efficiency (35.5%) and a remarkable surface plasmonic effect (both properties are approximately twofold higher than those of 50 nm Au nanoparticles). In contrast to the siRNA/miRNA delivery methods, the antagomiR delivery is based on strand displacement, in which the antagomiR-152 is displaced by oncomiR-152 followed by a surface-enhanced Raman spectroscopy signal drop. This enables both cancer cell diagnosis and in vitro real-time monitoring of the antagomiR release. This selective PTT nanoparticle can also efficiently target solid tumors and undergo in vivo PTT, indicating its potential clinical applications.
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Full text: 1 Database: MEDLINE Main subject: Phototherapy / Organoselenium Compounds / Metal Nanoparticles / Antagomirs / Gold Language: En Journal: Small Journal subject: ENGENHARIA BIOMEDICA Year: 2018 Type: Article

Full text: 1 Database: MEDLINE Main subject: Phototherapy / Organoselenium Compounds / Metal Nanoparticles / Antagomirs / Gold Language: En Journal: Small Journal subject: ENGENHARIA BIOMEDICA Year: 2018 Type: Article