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SuPAR, an emerging biomarker in kidney and inflammatory diseases.
Hamie, Lamiaa; Daoud, Georges; Nemer, Georges; Nammour, Tarek; El Chediak, Alissar; Uthman, Imad W; Kibbi, Abdul Ghani; Eid, Assaad; Kurban, Mazen.
Affiliation
  • Hamie L; Department of Anatomy, Cell Biology and Physiological Sciences, Faculty of Medicine, American University of Beirut, Beirut, Lebanon.
  • Daoud G; Department of Anatomy, Cell Biology and Physiological Sciences, Faculty of Medicine, American University of Beirut, Beirut, Lebanon.
  • Nemer G; Department of Biochemistry and Molecular Genetics, Faculty of Medicine, American University of Beirut, Beirut, Lebanon.
  • Nammour T; Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon.
  • El Chediak A; Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon.
  • Uthman IW; Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon.
  • Kibbi AG; Department of Dermatology, American University of Beirut Medical Center, Beirut, Lebanon.
  • Eid A; Department of Anatomy, Cell Biology and Physiological Sciences, Faculty of Medicine, American University of Beirut, Beirut, Lebanon.
  • Kurban M; Department of Biochemistry and Molecular Genetics, Faculty of Medicine, American University of Beirut, Beirut, Lebanon mk104@aub.edu.lb.
Postgrad Med J ; 94(1115): 517-524, 2018 Sep.
Article in En | MEDLINE | ID: mdl-30177549
ABSTRACT
Soluble urokinase plasminogen activator receptor (suPAR) is a circulating form of a physiological and pathophysiological important cell surface receptor, implicated in inflammation. Recent studies showed that suPAR is a promising biomarker, useful for diagnosis, assessment and prognosis of several diseases. This review summarises the majority of preliminary studies and analyses the significance and the clinical application of suPAR in various clinical conditions. SuPAR seems to have a significant value in the diagnosis as well as prognosis of many diseases; nonetheless, it merits large-scale studies to set cut-off values that help physicians in following up their patients and accordingly tailor their treatment plans.
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Full text: 1 Database: MEDLINE Main subject: Biomarkers / Receptors, Urokinase Plasminogen Activator / Inflammation / Kidney Diseases Type of study: Prognostic_studies Limits: Humans Language: En Journal: Postgrad Med J Year: 2018 Type: Article Affiliation country: Lebanon
Fulltext
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Full text: 1 Database: MEDLINE Main subject: Biomarkers / Receptors, Urokinase Plasminogen Activator / Inflammation / Kidney Diseases Type of study: Prognostic_studies Limits: Humans Language: En Journal: Postgrad Med J Year: 2018 Type: Article Affiliation country: Lebanon