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A systems-level framework for drug discovery identifies Csf1R as an anti-epileptic drug target.
Srivastava, Prashant K; van Eyll, Jonathan; Godard, Patrice; Mazzuferi, Manuela; Delahaye-Duriez, Andree; Van Steenwinckel, Juliette; Gressens, Pierre; Danis, Benedicte; Vandenplas, Catherine; Foerch, Patrik; Leclercq, Karine; Mairet-Coello, Georges; Cardenas, Alvaro; Vanclef, Frederic; Laaniste, Liisi; Niespodziany, Isabelle; Keaney, James; Gasser, Julien; Gillet, Gaelle; Shkura, Kirill; Chong, Seon-Ah; Behmoaras, Jacques; Kadiu, Irena; Petretto, Enrico; Kaminski, Rafal M; Johnson, Michael R.
Affiliation
  • Srivastava PK; Division of Brain Sciences, Imperial College London, London, W12 0NN, UK.
  • van Eyll J; UCB Pharma, Avenue de l'industrie, Braine-l'Alleud, R9, B-1420, Belgium.
  • Godard P; Clarivate Analytics (formerly the IP & Science Business of Thomson Reuters), 5901 Priestly Drive, #200, Carlsbad, CA, 92008, USA.
  • Mazzuferi M; UCB Pharma, Avenue de l'industrie, Braine-l'Alleud, R9, B-1420, Belgium.
  • Delahaye-Duriez A; Division of Brain Sciences, Imperial College London, London, W12 0NN, UK.
  • Van Steenwinckel J; UFR de Santé, Médecine et Biologie Humaine, Sorbonne Paris Cité, Université Paris 13, Bobigny, France.
  • Gressens P; PROTECT, INSERM, Sorbonne Paris Cité, Université Paris Diderot, Paris, France.
  • Danis B; PROTECT, INSERM, Sorbonne Paris Cité, Université Paris Diderot, Paris, France.
  • Vandenplas C; PROTECT, INSERM, Sorbonne Paris Cité, Université Paris Diderot, Paris, France.
  • Foerch P; School of Biomedical Engineering & Imaging Sciences, Centre for the Developing Brain, King's College London, St. Thomas' Hospital, London, SE1 7EH, UK.
  • Leclercq K; UCB Pharma, Avenue de l'industrie, Braine-l'Alleud, R9, B-1420, Belgium.
  • Mairet-Coello G; UCB Pharma, Avenue de l'industrie, Braine-l'Alleud, R9, B-1420, Belgium.
  • Cardenas A; UCB Pharma, Avenue de l'industrie, Braine-l'Alleud, R9, B-1420, Belgium.
  • Vanclef F; UCB Pharma, Avenue de l'industrie, Braine-l'Alleud, R9, B-1420, Belgium.
  • Laaniste L; UCB Pharma, Avenue de l'industrie, Braine-l'Alleud, R9, B-1420, Belgium.
  • Niespodziany I; UCB Pharma, Avenue de l'industrie, Braine-l'Alleud, R9, B-1420, Belgium.
  • Keaney J; UCB Pharma, Avenue de l'industrie, Braine-l'Alleud, R9, B-1420, Belgium.
  • Gasser J; Division of Brain Sciences, Imperial College London, London, W12 0NN, UK.
  • Gillet G; UCB Pharma, Avenue de l'industrie, Braine-l'Alleud, R9, B-1420, Belgium.
  • Shkura K; UCB Pharma, Avenue de l'industrie, Braine-l'Alleud, R9, B-1420, Belgium.
  • Chong SA; UCB Pharma, Avenue de l'industrie, Braine-l'Alleud, R9, B-1420, Belgium.
  • Behmoaras J; UCB Pharma, Avenue de l'industrie, Braine-l'Alleud, R9, B-1420, Belgium.
  • Kadiu I; Division of Brain Sciences, Imperial College London, London, W12 0NN, UK.
  • Petretto E; UCB Pharma, Avenue de l'industrie, Braine-l'Alleud, R9, B-1420, Belgium.
  • Kaminski RM; Centre for Complement and Inflammation Research, Imperial College London, London, W12 0NN, UK.
  • Johnson MR; UCB Pharma, Avenue de l'industrie, Braine-l'Alleud, R9, B-1420, Belgium.
Nat Commun ; 9(1): 3561, 2018 09 03.
Article in En | MEDLINE | ID: mdl-30177815

Full text: 1 Database: MEDLINE Main subject: Receptors, Granulocyte-Macrophage Colony-Stimulating Factor / Epilepsy / Epilepsy, Temporal Lobe / Anticonvulsants Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2018 Type: Article Affiliation country: United kingdom

Full text: 1 Database: MEDLINE Main subject: Receptors, Granulocyte-Macrophage Colony-Stimulating Factor / Epilepsy / Epilepsy, Temporal Lobe / Anticonvulsants Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2018 Type: Article Affiliation country: United kingdom