Epigenetic Regulation of Human Neural Stem Cell Differentiation.
Results Probl Cell Differ
; 66: 125-136, 2018.
Article
in En
| MEDLINE
| ID: mdl-30209657
ABSTRACT
Emerging evidence has demonstrated that epigenetic programs influence many aspects of neural stem cell (NSC) behavior, including proliferation and differentiation. It is becoming apparent that epigenetic mechanisms, such as DNA methylation, histone modifications, and noncoding RNA expression, are spatiotemporally regulated and that these intracellular programs, in concert with extracellular signals, ensure appropriate gene activation. Here we summarize recent advances in understanding of the epigenetic regulation of human NSCs directly isolated from the brain or produced from pluripotent stem cells (embryonic and induced pluripotent stem cells, respectively).
Full text:
1
Database:
MEDLINE
Main subject:
Cell Differentiation
/
Epigenesis, Genetic
/
Neural Stem Cells
Limits:
Humans
Language:
En
Journal:
Results Probl Cell Differ
Year:
2018
Type:
Article
Affiliation country:
Japan