Characterization of neuroinflammation and periphery-to-CNS inflammatory cross-talk in patients with disc herniation and degenerative disc disease.

Palada, Vinko; Ahmed, Aisha Siddiqah; Finn, Anja; Berg, Svante; Svensson, Camilla I; Kosek, Eva

Palada, Vinko; Ahmed, Aisha Siddiqah; Finn, Anja; Berg, Svante; Svensson, Camilla I; Kosek, Eva.

Affiliation

Palada V; Department of Physiology and Pharmacology, Karolinska Institutet, 17177 Stockholm, Sweden.
Ahmed AS; Department of Clinical Neuroscience, Karolinska Institutet, Department of Neuroradiology, Karolinska University Hospital, 17177 Stockholm, Sweden.
Finn A; Department of Physiology and Pharmacology, Karolinska Institutet, 17177 Stockholm, Sweden.
Berg S; Stockholm Spine Center, 19489 Upplands Väsby, Sweden.
Svensson CI; Department of Physiology and Pharmacology, Karolinska Institutet, 17177 Stockholm, Sweden.
Kosek E; Department of Clinical Neuroscience, Karolinska Institutet, Department of Neuroradiology, Karolinska University Hospital, 17177 Stockholm, Sweden. Electronic address: Eva.Kosek@ki.se.

Brain Behav Immun ; 75: 60-71, 2019 01.

Article in En | MEDLINE | ID: mdl-30248387

Subject(s)

Intervertebral Disc Degeneration/immunology; Intervertebral Disc Displacement/immunology; Pain/immunology; Adult; Aged; Chemokines/metabolism; Cytokines/metabolism; Female; Humans; Interleukin-6/analysis; Interleukin-6/blood; Interleukin-6/cerebrospinal fluid; Interleukin-8/analysis; Interleukin-8/blood; Interleukin-8/cerebrospinal fluid; Intervertebral Disc; Intervertebral Disc Degeneration/physiopathology; Intervertebral Disc Displacement/blood; Intervertebral Disc Displacement/physiopathology; Low Back Pain; Lumbar Vertebrae; Male; Middle Aged; Neuroimmunomodulation/immunology; Neuroimmunomodulation/physiology; Pain/metabolism; Receptors, GABA/analysis; Receptors, GABA/blood

Key words

Chemokines; Cytokines; Degenerative disc disease (DDD); Interleukin-6 (IL-6); Interleukin-8 (IL-8); Intervertebral discs; Low back pain (LBP); Lumbar disc herniation (LDH); Monocyte chemotactic protein 1 (MCP1); Neuroinflammation; The translocator protein (TSPO)

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Full text: 1 Database: MEDLINE Main subject: Pain / Intervertebral Disc Degeneration / Intervertebral Disc Displacement Type of study: Prognostic_studies Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: En Journal: Brain Behav Immun Journal subject: ALERGIA E IMUNOLOGIA / CEREBRO / PSICOFISIOLOGIA Year: 2019 Type: Article Affiliation country: Sweden

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