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Pulse Oximeter Saturation Targeting and Oximeter Changes in the Benefits of Oxygen Saturation Targeting (BOOST)-II Australia and BOOST-II UK Oxygen Trials.
Stenson, Benjamin J; Donoghoe, Mark; Brocklehurst, Peter; Davis, Peter G; Juszczak, Edmund; Marschner, Ian C; Simes, John; Tarnow-Mordi, William O.
Affiliation
  • Stenson BJ; Neonatal Unit, Royal Infirmary of Edinburgh, Edinburgh, United Kingdom. Electronic address: ben.stenson@luht.scot.nhs.uk.
  • Donoghoe M; NHMRC Clinical Trials Centre, University of Sydney, Sydney, NSW, Australia.
  • Brocklehurst P; Birmingham Clinical Trials Unit, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom.
  • Davis PG; The Royal Women's Hospital, Department of Obstetrics and Gynecology, The University of Melbourne; Murdoch Children's Research Institute Melbourne, Melbourne, Australia.
  • Juszczak E; National Perinatal Epidemiology Unit Clinical Trials Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom.
  • Marschner IC; NHMRC Clinical Trials Centre, University of Sydney, Sydney, NSW, Australia; Department of Statistics, Macquarie University, Sydney, NSW, Australia.
  • Simes J; NHMRC Clinical Trials Centre, University of Sydney, Sydney, NSW, Australia.
  • Tarnow-Mordi WO; NHMRC Clinical Trials Centre, University of Sydney, Sydney, NSW, Australia.
J Pediatr ; 204: 301-304.e2, 2019 01.
Article in En | MEDLINE | ID: mdl-30314661
ABSTRACT
Infants in the Australian and UK Benefits of Oxygen Saturation Targeting-II trials treated using revised oximeters spent more time within their planned pulse oximeter saturation target ranges than infants treated using the original oximeters (P < .001). This may explain the larger mortality difference seen with revised oximeters. If so, average treatment effects from the Neonatal Oxygen Prospective Meta-analysis trials may be underestimates.
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Full text: 1 Database: MEDLINE Main subject: Oxygen / Oximetry / Infant Mortality Type of study: Systematic_reviews Limits: Humans / Infant / Newborn Country/Region as subject: Europa / Oceania Language: En Journal: J Pediatr Year: 2019 Type: Article
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Full text: 1 Database: MEDLINE Main subject: Oxygen / Oximetry / Infant Mortality Type of study: Systematic_reviews Limits: Humans / Infant / Newborn Country/Region as subject: Europa / Oceania Language: En Journal: J Pediatr Year: 2019 Type: Article