HLA class I and II alleles in susceptibility to ankylosing spondylitis.
Ann Rheum Dis
; 78(1): 66-73, 2019 01.
Article
in En
| MEDLINE
| ID: mdl-30341055
ABSTRACT
OBJECTIVE:
To examine associations of HLA class I and class II alleles with ankylosing spondylitis (AS) in three cohorts of patients of European, Asian and African ancestry.METHODS:
HLA-A, HLA-B, HLA-C, HLA-DRB1, HLA-DQB1 and HLA-DPB1 alleles were genotyped in 1948 unrelated white and 67 African-American patients with AS from the Prospective Study of Outcomes in Ankylosing Spondylitis cohort, the North American Spondylitis Consortium and Australo-Anglo-American Spondyloarthritis Consortium, 990 white and 245 African-American Controls and HLA-B alleles in 442 Han Chinese patients with AS and 346 controls from Shanghai and Gansu, China. In addition to the casecontrol analyses, HLA-B*27-negative patients with AS were analysed separately, and logistic regression and 'relative predispositional effects' (RPE) analyses were carried out to control for the major effect of HLA-B*27 on disease susceptibility.RESULTS:
Although numerous associations were seen between HLA alleles and AS in whites, among HLA-B*27-negative patients with AS , positive associations were seen with HLA-A*29, B*38, B*49, B*52, DRB1*11 and DPB1*0301 and negative associations with HLA-B*07, HLA-B*57, HLA-DRB1*1501, HLA-DQB1*0201 and HLA-DQB1*0602. Additional associations with HLA-B*14 and B*40 (B60) were observed via RPE analysis, which excludes the HLA-B*27 alleles. The increased frequency of HLA-B*4001 and decreased frequency of HLA-B*07 was also seen in Han Chinese and African-Americans with AS. HLA-B*08 was decreased in whites with acute anterior uveitis.CONCLUSIONS:
These data, analysing the largest number of patients with AS examined to date in three ethnic groups, confirm that other HLA class I and II alleles other than HLA-B*27 to be operative in AS predisposition.Key words
Full text:
1
Database:
MEDLINE
Main subject:
Spondylitis, Ankylosing
/
Histocompatibility Antigens Class I
/
Histocompatibility Antigens Class II
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Genetic Predisposition to Disease
/
Racial Groups
Type of study:
Evaluation_studies
/
Observational_studies
/
Risk_factors_studies
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
En
Journal:
Ann Rheum Dis
Year:
2019
Type:
Article
Affiliation country:
United States