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Hearing treatment for reducing cognitive decline: Design and methods of the Aging and Cognitive Health Evaluation in Elders randomized controlled trial.
Deal, Jennifer A; Goman, Adele M; Albert, Marilyn S; Arnold, Michelle L; Burgard, Sheila; Chisolm, Theresa; Couper, David; Glynn, Nancy W; Gmelin, Theresa; Hayden, Kathleen M; Mosley, Thomas; Pankow, James S; Reed, Nicholas; Sanchez, Victoria A; Richey Sharrett, A; Thomas, Sonia D; Coresh, Josef; Lin, Frank R.
Affiliation
  • Deal JA; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
  • Goman AM; Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins School of Medicine, Baltimore, MD, USA.
  • Albert MS; Cochlear Center for Hearing and Public Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
  • Arnold ML; Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins School of Medicine, Baltimore, MD, USA.
  • Burgard S; Cochlear Center for Hearing and Public Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
  • Chisolm T; Department of Neurology, Johns Hopkins School of Medicine, Baltimore, MD, USA.
  • Couper D; College of Science and Mathematics, University of South Florida Sarasota - Manatee, Sarasota, FL, USA.
  • Glynn NW; Department of Biostatistics, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA.
  • Gmelin T; Department of Communication Sciences and Disorders, University of South Florida, Tampa, FL, USA.
  • Hayden KM; Department of Biostatistics, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA.
  • Mosley T; Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA, USA.
  • Pankow JS; Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.
  • Reed N; Department of Social Sciences and Health Policy, Wake Forest School of Medicine, Winston-Salem, NC, USA.
  • Sanchez VA; The MIND Center, University of Mississippi Medical Center, Jackson, MS, USA.
  • Richey Sharrett A; Division of Epidemiology and Community Health, University of Minnesota School of Public Health, Minneapolis, MN, USA.
  • Thomas SD; Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins School of Medicine, Baltimore, MD, USA.
  • Coresh J; Cochlear Center for Hearing and Public Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
  • Lin FR; Department of Otolaryngology-Head and Neck Surgery, University of South Florida, Tampa, FL, USA.
Alzheimers Dement (N Y) ; 4: 499-507, 2018.
Article in En | MEDLINE | ID: mdl-30364572
ABSTRACT

INTRODUCTION:

Hearing impairment is highly prevalent and independently associated with cognitive decline. The Aging and Cognitive Health Evaluation in Elders study is a multicenter randomized controlled trial to determine efficacy of hearing treatment in reducing cognitive decline in older adults. Clinicaltrials.gov Identifier NCT03243422.

METHODS:

Eight hundred fifty participants without dementia aged 70 to 84 years with mild-to-moderate hearing impairment recruited from four United States field sites and randomized 11 to a best-practices hearing intervention or health education control. Primary study outcome is 3-year change in global cognitive function. Secondary outcomes include domain-specific cognitive decline, incident dementia, brain structural changes on magnetic resonance imaging, health-related quality of life, physical and social function, and physical activity.

RESULTS:

Trial enrollment began January 4, 2018 and is ongoing.

DISCUSSION:

When completed in 2022, Aging and Cognitive Health Evaluation in Elders study should provide definitive evidence of the effect of hearing treatment versus education control on cognitive decline in community-dwelling older adults with mild-to-moderate hearing impairment.
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Full text: 1 Database: MEDLINE Type of study: Clinical_trials / Guideline / Risk_factors_studies Language: En Journal: Alzheimers Dement (N Y) Year: 2018 Type: Article Affiliation country: United States
Fulltext
Add to My VHL
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PubMed Links
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Full text: 1 Database: MEDLINE Type of study: Clinical_trials / Guideline / Risk_factors_studies Language: En Journal: Alzheimers Dement (N Y) Year: 2018 Type: Article Affiliation country: United States