Design, synthesis, and biological evaluation of Helicobacter pylori inosine 5'-monophosphate dehydrogenase (HpIMPDH) inhibitors.

Sahu, Niteshkumar U; Purushothaman, Gayathri; Thiruvenkatam, Vijay; Kharkar, Prashant S

Sahu, Niteshkumar U; Purushothaman, Gayathri; Thiruvenkatam, Vijay; Kharkar, Prashant S.

Affiliation

Sahu NU; Department of Pharmaceutical Chemistry, Shobhaben Pratapbhai Patel School of Pharmacy and Technology Management, SVKM's NMIMS, Mumbai, India.
Purushothaman G; Biological Engineering, Indian Institute of Technology Gandhinagar, Gujarat, India.
Thiruvenkatam V; Biological Engineering, Indian Institute of Technology Gandhinagar, Gujarat, India.
Kharkar PS; Physics, Indian Institute of Technology Gandhinagar, Gujarat, India.

Drug Dev Res ; 80(1): 125-132, 2019 02.

Article in En | MEDLINE | ID: mdl-30381846

Subject(s)

Anti-Bacterial Agents/pharmacology; Drug Design; Enzyme Inhibitors/pharmacology; Helicobacter pylori/drug effects; Helicobacter pylori/enzymology; IMP Dehydrogenase/antagonists & inhibitors; Anti-Bacterial Agents/chemical synthesis; Drug Evaluation, Preclinical/methods; Enzyme Inhibitors/chemical synthesis; Humans; IMP Dehydrogenase/metabolism; Molecular Docking Simulation/methods; Structure-Activity Relationship

Key words

1,2,3-triazole; Helicobacter pylori; HpIMPDH; IMPDH; flavone; hIMPDH2

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Full text: 1 Database: MEDLINE Main subject: Drug Design / Helicobacter pylori / Enzyme Inhibitors / IMP Dehydrogenase / Anti-Bacterial Agents Limits: Humans Language: En Journal: Drug Dev Res Year: 2019 Type: Article Affiliation country: India

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