Rh-Catalyzed aminative dearomatization of 2-naphthols.
Org Biomol Chem
; 16(45): 8700-8703, 2018 11 21.
Article
in En
| MEDLINE
| ID: mdl-30406793
ABSTRACT
A direct aminative dearomatization of 2-naphthols was achieved. In the presence of 1 mol% Rh2(esp)2 and 3 equivalents of O-(2,4-dinitrophenyl)hydroxylamine (DPH) as readily available aminating reagents, the reactions of 2-naphthols afforded unprotected α-amino-ß-naphthalenones in good yields under mild reaction conditions. The conditions were compatible with gram-scale reaction, and the product could undergo diverse transformations.
Full text:
1
Database:
MEDLINE
Language:
En
Journal:
Org Biomol Chem
Journal subject:
BIOQUIMICA
/
QUIMICA
Year:
2018
Type:
Article
Affiliation country:
China