Halogenated Meroditerpenoids from a South Pacific Collection of the Red Alga Callophycus serratus.
J Nat Prod
; 81(11): 2446-2454, 2018 11 26.
Article
in En
| MEDLINE
| ID: mdl-30407005
ABSTRACT
A detailed examination of the red alga Callophycus serratus collected in Tonga led to the isolation of six new halogenated meroditerpenoids callophycol C (1), callophycoic acid I (2), iodocallophycols E (3) and F (4), iodocallophycoic acid B (5), and callophycoic acid J (6). Of these, compounds 3-5 are new iodinated additions to the growing family of Callophycus meroditerpenoids. The relative configurations of compounds 1-6 were deduced by analyses of 1D NOE data and 1H-1H scalar coupling constants, and 3-6 are proposed to differ from the closely related compounds reported in the literature, iodocallophycoic acid A and iodocallophycols A-D. Iodocallophycol E (3) exhibited moderate cytotoxicity against the promyelocytic leukemia cell line HL-60 with an IC50 value of 6.0 µM.
Full text:
1
Database:
MEDLINE
Main subject:
Diterpenes
/
Rhodophyta
Limits:
Humans
Language:
En
Journal:
J Nat Prod
Year:
2018
Type:
Article