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Design, Synthesis and Characterization of Covalent KDM5 Inhibitors.
Vazquez-Rodriguez, Saleta; Wright, Miranda; Rogers, Catherine M; Cribbs, Adam P; Velupillai, Srikannathasan; Philpott, Martin; Lee, Henry; Dunford, James E; Huber, Kilian V M; Robers, Matthew B; Vasta, James D; Thezenas, Marie-Laetitia; Bonham, Sarah; Kessler, Benedikt; Bennett, James; Fedorov, Oleg; Raynaud, Florence; Donovan, Adam; Blagg, Julian; Bavetsias, Vassilios; Oppermann, Udo; Bountra, Chas; Kawamura, Akane; Brennan, Paul E.
Affiliation
  • Vazquez-Rodriguez S; Structural Genomics Consortium & Target Discovery Institute, University of Oxford, NDM Research Building, Roosevelt Drive, Oxford, OX3 7DQ and OX3 7FZ, UK.
  • Wright M; Structural Genomics Consortium & Target Discovery Institute, University of Oxford, NDM Research Building, Roosevelt Drive, Oxford, OX3 7DQ and OX3 7FZ, UK.
  • Rogers CM; Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford, OX1 3TA, UK.
  • Cribbs AP; Structural Genomics Consortium & Target Discovery Institute, University of Oxford, NDM Research Building, Roosevelt Drive, Oxford, OX3 7DQ and OX3 7FZ, UK.
  • Velupillai S; Botnar Research Center, Nuffield Department of Orthopedics, Rheumatology and Musculoskeletal Sciences, NIHR Oxford BRC, University of Oxford, Oxford, OX3 7DQ, UK.
  • Philpott M; Structural Genomics Consortium & Target Discovery Institute, University of Oxford, NDM Research Building, Roosevelt Drive, Oxford, OX3 7DQ and OX3 7FZ, UK.
  • Lee H; Botnar Research Center, Nuffield Department of Orthopedics, Rheumatology and Musculoskeletal Sciences, NIHR Oxford BRC, University of Oxford, Oxford, OX3 7DQ, UK.
  • Dunford JE; Botnar Research Center, Nuffield Department of Orthopedics, Rheumatology and Musculoskeletal Sciences, NIHR Oxford BRC, University of Oxford, Oxford, OX3 7DQ, UK.
  • Huber KVM; Botnar Research Center, Nuffield Department of Orthopedics, Rheumatology and Musculoskeletal Sciences, NIHR Oxford BRC, University of Oxford, Oxford, OX3 7DQ, UK.
  • Robers MB; Structural Genomics Consortium & Target Discovery Institute, University of Oxford, NDM Research Building, Roosevelt Drive, Oxford, OX3 7DQ and OX3 7FZ, UK.
  • Vasta JD; Promega Corporation, 2800 Woods Hollow Road, Fitchburg, WI, 53711, USA.
  • Thezenas ML; Promega Corporation, 2800 Woods Hollow Road, Fitchburg, WI, 53711, USA.
  • Bonham S; Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Roosevelt Drive, OX3 7FZ, Oxford, UK.
  • Kessler B; Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Roosevelt Drive, OX3 7FZ, Oxford, UK.
  • Bennett J; Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Roosevelt Drive, OX3 7FZ, Oxford, UK.
  • Fedorov O; Structural Genomics Consortium & Target Discovery Institute, University of Oxford, NDM Research Building, Roosevelt Drive, Oxford, OX3 7DQ and OX3 7FZ, UK.
  • Raynaud F; Structural Genomics Consortium & Target Discovery Institute, University of Oxford, NDM Research Building, Roosevelt Drive, Oxford, OX3 7DQ and OX3 7FZ, UK.
  • Donovan A; Cancer Research (UK) Cancer Therapeutics Unit, The Institute of Cancer Research, 15 Cotswold Road, London, SM2 5NG, UK.
  • Blagg J; Cancer Research (UK) Cancer Therapeutics Unit, The Institute of Cancer Research, 15 Cotswold Road, London, SM2 5NG, UK.
  • Bavetsias V; Cancer Research (UK) Cancer Therapeutics Unit, The Institute of Cancer Research, 15 Cotswold Road, London, SM2 5NG, UK.
  • Oppermann U; Cancer Research (UK) Cancer Therapeutics Unit, The Institute of Cancer Research, 15 Cotswold Road, London, SM2 5NG, UK.
  • Bountra C; Structural Genomics Consortium & Target Discovery Institute, University of Oxford, NDM Research Building, Roosevelt Drive, Oxford, OX3 7DQ and OX3 7FZ, UK.
  • Kawamura A; Botnar Research Center, Nuffield Department of Orthopedics, Rheumatology and Musculoskeletal Sciences, NIHR Oxford BRC, University of Oxford, Oxford, OX3 7DQ, UK.
  • Brennan PE; FRIAS-Freiburg Institute of Advanced Studies, 79104, Freiburg, Germany.
Angew Chem Int Ed Engl ; 58(2): 515-519, 2019 01 08.
Article in En | MEDLINE | ID: mdl-30431220
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Full text: 1 Database: MEDLINE Language: En Journal: Angew Chem Int Ed Engl Year: 2019 Type: Article Affiliation country: United kingdom
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Full text: 1 Database: MEDLINE Language: En Journal: Angew Chem Int Ed Engl Year: 2019 Type: Article Affiliation country: United kingdom