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Targeted degradation of BRD9 reverses oncogenic gene expression in synovial sarcoma.
Brien, Gerard L; Remillard, David; Shi, Junwei; Hemming, Matthew L; Chabon, Jonathon; Wynne, Kieran; Dillon, Eugène T; Cagney, Gerard; Van Mierlo, Guido; Baltissen, Marijke P; Vermeulen, Michiel; Qi, Jun; Fröhling, Stefan; Gray, Nathanael S; Bradner, James E; Vakoc, Christopher R; Armstrong, Scott A.
Affiliation
  • Brien GL; Department of Pediatric Oncology, Dana Farber Cancer Institute, Boston Children's Hospital and Harvard Medical School, Boston, United States.
  • Remillard D; Smurfit Institute of Genetics, Trinity College Dublin, Dublin, Ireland.
  • Shi J; Department of Medical Oncology, Dana Farber Cancer Institute, Boston Children's Hospital and Harvard Medical School, Boston, United States.
  • Hemming ML; Department of Cancer Biology, Dana Farber Cancer Institute, Boston Children's Hospital and Harvard Medical School, Boston, United States.
  • Chabon J; Department of Cancer Biology, Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States.
  • Wynne K; Department of Pediatric Oncology, Dana Farber Cancer Institute, Boston Children's Hospital and Harvard Medical School, Boston, United States.
  • Dillon ET; Department of Medical Oncology, Dana Farber Cancer Institute, Boston Children's Hospital and Harvard Medical School, Boston, United States.
  • Cagney G; Department of Pediatric Oncology, Dana Farber Cancer Institute, Boston Children's Hospital and Harvard Medical School, Boston, United States.
  • Van Mierlo G; School of Biomolecular and Biomedical Science and Conway Institute, University College Dublin, Dublin, Ireland.
  • Baltissen MP; School of Biomolecular and Biomedical Science and Conway Institute, University College Dublin, Dublin, Ireland.
  • Vermeulen M; School of Biomolecular and Biomedical Science and Conway Institute, University College Dublin, Dublin, Ireland.
  • Qi J; Department of Molecular Biology, Faculty of Science, Radboud Institute for Molecular Life Sciences, Oncode Institute, Radboud University Nijmegen, Nijmegen, The Netherlands.
  • Fröhling S; Department of Molecular Biology, Faculty of Science, Radboud Institute for Molecular Life Sciences, Oncode Institute, Radboud University Nijmegen, Nijmegen, The Netherlands.
  • Gray NS; Department of Molecular Biology, Faculty of Science, Radboud Institute for Molecular Life Sciences, Oncode Institute, Radboud University Nijmegen, Nijmegen, The Netherlands.
  • Bradner JE; Department of Cancer Biology, Dana Farber Cancer Institute, Boston Children's Hospital and Harvard Medical School, Boston, United States.
  • Vakoc CR; German Cancer Consortium, Heidelberg, Germany.
  • Armstrong SA; Section for Personalized Oncology, Heidelberg University Hospital, Heidelberg, Germany.
Elife ; 72018 11 15.
Article in En | MEDLINE | ID: mdl-30431433
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Full text: 1 Database: MEDLINE Main subject: Transcription Factors / Gene Expression Regulation, Neoplastic / Sarcoma, Synovial / Proteolysis Type of study: Prognostic_studies Limits: Humans Language: En Journal: Elife Year: 2018 Type: Article Affiliation country: United States
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Full text: 1 Database: MEDLINE Main subject: Transcription Factors / Gene Expression Regulation, Neoplastic / Sarcoma, Synovial / Proteolysis Type of study: Prognostic_studies Limits: Humans Language: En Journal: Elife Year: 2018 Type: Article Affiliation country: United States