smartPearls - Novel physically stable amorphous delivery system for poorly soluble dermal actives.

Müller, Rainer H; Hespeler, David; Jin, Nan; Pyo, Sung Min

Müller, Rainer H; Hespeler, David; Jin, Nan; Pyo, Sung Min.

Affiliation

Müller RH; Freie Universität Berlin, Institute of Pharmacy, Germany.
Hespeler D; Freie Universität Berlin, Institute of Pharmacy, Germany.
Jin N; Freie Universität Berlin, Institute of Pharmacy, Germany.
Pyo SM; Freie Universität Berlin, Institute of Pharmacy, Germany. Electronic address: pyo.sungmin@fu-berlin.de.

Int J Pharm ; 555: 314-321, 2019 Jan 30.

Article in En | MEDLINE | ID: mdl-30439490

Subject(s)

Cosmetics/administration & dosage; Drug Delivery Systems; Pharmaceutical Preparations/administration & dosage; Administration, Cutaneous; Chemistry, Pharmaceutical/methods; Cosmetics/chemistry; Cosmetics/pharmacokinetics; Excipients/chemistry; Humans; Particle Size; Pharmaceutical Preparations/chemistry; Pharmaceutical Preparations/metabolism; Skin Absorption; Solubility; Technology, Pharmaceutical/methods

Key words

amorphous actives; dermal delivery system; enhanced bioavailability; increased saturation solubility; mesoporous silica; smartPearls

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Full text: 1 Database: MEDLINE Main subject: Pharmaceutical Preparations / Drug Delivery Systems / Cosmetics Limits: Humans Language: En Journal: Int J Pharm Year: 2019 Type: Article Affiliation country: Germany

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