Prognostic factors and survival in adenoid cystic carcinoma of the sinonasal cavity.
Head Neck
; 40(12): 2596-2605, 2018 12.
Article
in En
| MEDLINE
| ID: mdl-30447126
ABSTRACT
BACKGROUND:
Optimal treatment and prognostic factors affecting long-term survival in patients with sinonasal adenoid cystic carcinoma (ACC) have yet to be clearly defined.METHODS:
We conducted a retrospective review of patients treated with curative intent from 1980-2015 at MD Anderson Cancer Center.RESULTS:
One hundred sixty patients met inclusion criteria, including 8 who were treated with radiotherapy alone. Median follow-up time was 55 months. The 5-year overall survival (OS) and disease-free survival (DFS) rates were 67.0% and 49.0%, respectively. The 10-year OS and DFS rates were 44.8% and 25.4%, respectively. Factors that portended for poor survival on multivariate analysis were recurrent disease, any solid type histology, epicenter in the sinus cavity, the presence of facial symptoms, or the original disease not treated with surgery. There was no association between surgical margin status or nodal status and survival.CONCLUSION:
In this large cohort of patients with sinonasal ACC with extended follow-up, long-term survival is better than reported in prior literature. Future research should target patients with adverse risk factors.Key words
Full text:
1
Database:
MEDLINE
Main subject:
Paranasal Sinus Neoplasms
/
Carcinoma, Adenoid Cystic
Type of study:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Head Neck
Journal subject:
NEOPLASIAS
Year:
2018
Type:
Article