Development, Characterization, and Pharmacokinetic Evaluation of a CRV431 Loaded Self-Microemulsifying Drug Delivery System.

Trepanier, Daniel J; Ure, Daren R; Foster, Robert Thomas

Trepanier, Daniel J; Ure, Daren R; Foster, Robert Thomas.

Affiliation

Trepanier DJ; ContraVir Pharmaceuticals Inc. Edmonton, Alberta, Canada.

J Pharm Pharm Sci ; 21(1s): 335s-348s, 2018.

Article in En | MEDLINE | ID: mdl-30472978

Subject(s)

Cyclosporins/pharmacokinetics; Drug Delivery Systems; Small Molecule Libraries/pharmacokinetics; Administration, Oral; Adolescent; Adult; Animals; Chromatography, Liquid; Cyclosporins/administration & dosage; Cyclosporins/chemistry; Emulsions/administration & dosage; Emulsions/chemistry; Emulsions/pharmacokinetics; Healthy Volunteers; Humans; Liver/chemistry; Liver/metabolism; Middle Aged; Molecular Conformation; Particle Size; Rats; Rats, Sprague-Dawley; Small Molecule Libraries/administration & dosage; Small Molecule Libraries/chemistry; Solubility; Spectrometry, Mass, Electrospray Ionization; Surface Properties; Tissue Distribution; Young Adult

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Full text: 1 Database: MEDLINE Main subject: Drug Delivery Systems / Cyclosporins / Small Molecule Libraries Limits: Adolescent / Adult / Animals / Humans / Middle aged Language: En Journal: J Pharm Pharm Sci Journal subject: FARMACIA / FARMACOLOGIA Year: 2018 Type: Article Affiliation country: Canada

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