Effects of intravitreal bevacizumab in Gram-positive and Gram-negative models of ocular inflammation.

Lafreniere, J Daniel; Toguri, James T; Gupta, Rishi R; Samad, Arif; O'Brien, Dan M; Dickinson, John; Cruess, Alan; Kelly, Melanie E M; Seamone, Mark E

Lafreniere, J Daniel; Toguri, James T; Gupta, Rishi R; Samad, Arif; O'Brien, Dan M; Dickinson, John; Cruess, Alan; Kelly, Melanie E M; Seamone, Mark E.

Affiliation

Lafreniere JD; Retina and Optic Nerve Research Laboratory, Department of Pharmacology, Dalhousie University, Halifax, Nova Scotia, Canada.
Toguri JT; Retina and Optic Nerve Research Laboratory, Department of Pharmacology, Dalhousie University, Halifax, Nova Scotia, Canada.
Gupta RR; Department of Ophthalmology and Visual Science, Dalhousie University, Halifax, Nova Scotia, Canada.
Samad A; Department of Ophthalmology and Visual Science, Dalhousie University, Halifax, Nova Scotia, Canada.
O'Brien DM; Department of Ophthalmology and Visual Science, Dalhousie University, Halifax, Nova Scotia, Canada.
Dickinson J; Department of Ophthalmology and Visual Science, Dalhousie University, Halifax, Nova Scotia, Canada.
Cruess A; Department of Ophthalmology and Visual Science, Dalhousie University, Halifax, Nova Scotia, Canada.
Kelly MEM; Retina and Optic Nerve Research Laboratory, Department of Pharmacology, Dalhousie University, Halifax, Nova Scotia, Canada.
Seamone ME; Department of Ophthalmology and Visual Science, Dalhousie University, Halifax, Nova Scotia, Canada.

Clin Exp Ophthalmol ; 47(5): 638-645, 2019 07.

Article in En | MEDLINE | ID: mdl-30485637

Subject(s)

Angiogenesis Inhibitors/therapeutic use; Bevacizumab/therapeutic use; Eye Infections, Bacterial/drug therapy; Gram-Negative Bacterial Infections/drug therapy; Gram-Positive Bacterial Infections/drug therapy; Uveitis/drug therapy; Animals; Cytokines/metabolism; Disease Models, Animal; Eye Infections, Bacterial/etiology; Eye Infections, Bacterial/metabolism; Gram-Negative Bacterial Infections/etiology; Gram-Negative Bacterial Infections/metabolism; Gram-Positive Bacterial Infections/etiology; Gram-Positive Bacterial Infections/metabolism; Inflammation/drug therapy; Inflammation/metabolism; Inflammation/microbiology; Intravitreal Injections; Lipopolysaccharides; Male; Mice; Mice, Inbred BALB C; Peptidoglycan; Time Factors; Uveitis/metabolism; Uveitis/microbiology; Vascular Endothelial Growth Factor A/antagonists & inhibitors; Vascular Endothelial Growth Factor A/metabolism

Key words

bevacizumab; lipopolysaccharide; ocular inflammation; peptidoglycan; vascular endothelial growth factor a

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Full text: 1 Database: MEDLINE Main subject: Uveitis / Eye Infections, Bacterial / Gram-Positive Bacterial Infections / Gram-Negative Bacterial Infections / Angiogenesis Inhibitors / Bevacizumab Type of study: Etiology_studies / Prognostic_studies Limits: Animals Language: En Journal: Clin Exp Ophthalmol Journal subject: OFTALMOLOGIA Year: 2019 Type: Article Affiliation country: Canada

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