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Marked thrombocytopenia in a neonate is associated with anti-HPA-5b, anti-HLA-A31, and anti-HLA-B55 antibodies.
Okubo, Mitsuo; Nishida, Eriko; Watanabe, Akiko; Nishizaki, Naoto; Obinata, Kaoru; Azuma, Fumihiro; Matsuhashi, Mika; Watanabe-Okochi, Naoko; Tsuno, Nelson Hirokazu; Miyake, Kazunori; Yamaguchi, Minoru; Yoshida, Koyo; Ohsaka, Akimichi.
Affiliation
  • Okubo M; Department of Transfusion Service, Juntendo University Urayasu Hospital, Urayasu City, Japan.
  • Nishida E; Department of Transfusion Medicine and Stem Cell Regulation, Juntendo University Graduate School of Medicine, Tokyo, Japan.
  • Watanabe A; Department of Pediatrics, Juntendo University Urayasu Hospital, Urayasu City, Japan.
  • Nishizaki N; Department of Pediatrics, Juntendo University Urayasu Hospital, Urayasu City, Japan.
  • Obinata K; Department of Pediatrics, Juntendo University Urayasu Hospital, Urayasu City, Japan.
  • Azuma F; Department of Pediatrics, Juntendo University Urayasu Hospital, Urayasu City, Japan.
  • Matsuhashi M; Laboratory Department, Kanto-Koshinetsu Block Blood Center, Japanese Red Cross, Tokyo, Japan.
  • Watanabe-Okochi N; Laboratory Department, Kanto-Koshinetsu Block Blood Center, Japanese Red Cross, Tokyo, Japan.
  • Tsuno NH; Laboratory Department, Kanto-Koshinetsu Block Blood Center, Japanese Red Cross, Tokyo, Japan.
  • Miyake K; Laboratory Department, Kanto-Koshinetsu Block Blood Center, Japanese Red Cross, Tokyo, Japan.
  • Yamaguchi M; Department of Laboratory Medicine, Juntendo University Urayasu Hospital, Urayasu City, Japan.
  • Yoshida K; Yamaguchi Hospital, Funabashi City, Japan.
  • Ohsaka A; Department of Obstetrics and Gynecology, Juntendo University Urayasu Hospital, Urayasu City, Japan.
Pediatr Blood Cancer ; 66(3): e27555, 2019 03.
Article in En | MEDLINE | ID: mdl-30488611
ABSTRACT
Maternal antibodies against human platelet antigen (HPA) and/or human leukocyte antigen (HLA) cause fetal and neonatal alloimmune thrombocytopenia (FNAIT) in 0.09-0.15% of live births. Severe cases account for 5-31% and the frequency of multiple kinds of alloantibodies is 6.9-9% of FNAIT. We present a case of severe FNAIT associated with anti-HPA-5b, anti-HLA-A31, and anti-HLA-B55 antibodies, successfully treated with immunoglobulin and platelet transfusion. The anti-HLA-B55 antibody was detected in the newborn's serum, but disappeared on the 20th day, which was followed by an increase of the platelet count. These findings suggested the potential involvement of an anti-HLA antibody in the pathogenesis of FNAIT.
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Full text: 1 Database: MEDLINE Main subject: HLA-A Antigens / HLA-B Antigens / Antigens, Human Platelet / Thrombocytopenia, Neonatal Alloimmune / Immunity, Maternally-Acquired / Isoantibodies Type of study: Prognostic_studies / Risk_factors_studies Limits: Adult / Female / Humans / Male / Newborn Language: En Journal: Pediatr Blood Cancer Journal subject: HEMATOLOGIA / NEOPLASIAS / PEDIATRIA Year: 2019 Type: Article Affiliation country: Japan
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Full text: 1 Database: MEDLINE Main subject: HLA-A Antigens / HLA-B Antigens / Antigens, Human Platelet / Thrombocytopenia, Neonatal Alloimmune / Immunity, Maternally-Acquired / Isoantibodies Type of study: Prognostic_studies / Risk_factors_studies Limits: Adult / Female / Humans / Male / Newborn Language: En Journal: Pediatr Blood Cancer Journal subject: HEMATOLOGIA / NEOPLASIAS / PEDIATRIA Year: 2019 Type: Article Affiliation country: Japan