A systematic review of randomized controlled trials investigating the efficacy and safety of testosterone therapy for female sexual dysfunction in postmenopausal women.
Clin Endocrinol (Oxf)
; 90(3): 391-414, 2019 03.
Article
in En
| MEDLINE
| ID: mdl-30488972
ABSTRACT
The clinical sequelae of oestrogen deficiency during menopause are undoubted. However, the pathophysiological role of testosterone during the menopause is less clear. Several randomized, placebo-controlled clinical trials suggest that testosterone therapy improves sexual function in postmenopausal women. Some studies suggest that testosterone therapy has additional effects, which include increased bone mineral density and decreased serum high-density lipoprotein (HDL) cholesterol. Furthermore, the long-term safety profile of testosterone therapy in postmenopausal women is not clear. This article will provide a concise and critical summary of the literature, to guide clinicians treating postmenopausal women.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Sexual Dysfunction, Physiological
/
Testosterone
/
Postmenopause
/
Androgens
Type of study:
Clinical_trials
/
Systematic_reviews
Limits:
Female
/
Humans
Language:
En
Journal:
Clin Endocrinol (Oxf)
Year:
2019
Type:
Article
Affiliation country:
United kingdom