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Discovery of a novel cathepsin inhibitor with dual autophagy-inducing and metastasis-inhibiting effects on breast cancer cells.
Yuan, Lei; Liu, Jun; He, Wenhui; Bao, Youmei; Sheng, Lei; Zou, Chunyang; Hu, Baichun; Ge, Wentao; Liu, Yang; Wang, Jian; Lin, Bin; Li, Yanchun; Ma, Enlong.
Affiliation
  • Yuan L; Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University), Ministry of Education, Shenyang 110016, PR China.
  • Liu J; Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University), Ministry of Education, Shenyang 110016, PR China.
  • He W; Department of Pharmacology, Shenyang Pharmaceutical University, Shenyang 110016, PR China.
  • Bao Y; School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, PR China.
  • Sheng L; Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University), Ministry of Education, Shenyang 110016, PR China.
  • Zou C; Department of Pharmacy, Liaoning Vocational College of Medicine, Shenyang 110101, PR China.
  • Hu B; Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University), Ministry of Education, Shenyang 110016, PR China.
  • Ge W; Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University), Ministry of Education, Shenyang 110016, PR China.
  • Liu Y; Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University), Ministry of Education, Shenyang 110016, PR China.
  • Wang J; Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University), Ministry of Education, Shenyang 110016, PR China.
  • Lin B; Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University), Ministry of Education, Shenyang 110016, PR China.
  • Li Y; GLP Center, Shenyang Pharmaceutical University, Shenyang 110016, PR China. Electronic address: liyanchun1971@sina.com.
  • Ma E; Department of Pharmacology, Shenyang Pharmaceutical University, Shenyang 110016, PR China. Electronic address: enlong_ma20180718@126.com.
Bioorg Chem ; 84: 239-253, 2019 03.
Article in En | MEDLINE | ID: mdl-30503850
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Full text: 1 Database: MEDLINE Main subject: Protease Inhibitors / Autophagy / Cathepsins Limits: Female / Humans Language: En Journal: Bioorg Chem Year: 2019 Type: Article
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Full text: 1 Database: MEDLINE Main subject: Protease Inhibitors / Autophagy / Cathepsins Limits: Female / Humans Language: En Journal: Bioorg Chem Year: 2019 Type: Article