LTD at mossy fiber synapses onto stratum lucidum interneurons requires TrkB and retrograde endocannabinoid signaling.

Pan, Enhui; Zhao, Zirun; McNamara, James O

Pan, Enhui; Zhao, Zirun; McNamara, James O.

Affiliation

Pan E; Department of Neurology, Duke University School of Medicine , Durham, North Carolina.
Zhao Z; Department of Neurobiology, Duke University School of Medicine , Durham, North Carolina.
McNamara JO; Department of Neurobiology, Duke University School of Medicine , Durham, North Carolina.

J Neurophysiol ; 121(2): 609-619, 2019 02 01.

Article in En | MEDLINE | ID: mdl-30517040

Subject(s)

CA3 Region, Hippocampal/metabolism; Interneurons/metabolism; Long-Term Synaptic Depression; Mossy Fibers, Hippocampal/metabolism; Receptor, Cannabinoid, CB1/metabolism; Receptor, trkB/metabolism; Animals; Brain-Derived Neurotrophic Factor/metabolism; CA3 Region, Hippocampal/cytology; CA3 Region, Hippocampal/physiology; Endocannabinoids/metabolism; Female; Glutamic Acid/metabolism; Interneurons/physiology; Male; Mice; Mossy Fibers, Hippocampal/physiology; Phospholipase C gamma/metabolism; Receptor, Cannabinoid, CB1/antagonists & inhibitors; Receptor, Cannabinoid, CB1/genetics; Signal Transduction

Key words

BDNF; TrkB; hippocampus; interneuron; synaptic plasticity

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Full text: 1 Database: MEDLINE Main subject: Mossy Fibers, Hippocampal / Receptor, trkB / Long-Term Synaptic Depression / Receptor, Cannabinoid, CB1 / CA3 Region, Hippocampal / Interneurons Type of study: Prognostic_studies Limits: Animals Language: En Journal: J Neurophysiol Year: 2019 Type: Article

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