Hydatidiform molar pregnancy following assisted reproduction.
J Assist Reprod Genet
; 36(4): 667-671, 2019 Apr.
Article
in En
| MEDLINE
| ID: mdl-30612209
ABSTRACT
INTRODUCTION:
The use of assisted reproduction techniques (ART) is increasing; however, reports of molar pregnancy following ART remain scarce. Currently, the Human Fertility and Embryology Authority (HFEA) collates data on the molar pregnancies that have resulted through the use of ART. Recently, they have indicated that they will no longer collect these data.AIM:
This paper aimed to examine the incidence of molar pregnancy amongst patients undergoing assisted reproduction.METHODS:
We contacted HFEA and placed a request under the Freedom of Information Act (2000) for the number of molar pregnancies that resulted from fresh/frozen embryo transfer since HFEA started collecting data in 1991 to February 2018. We also asked how many patients who had suffered a molar pregnancy went on to have a normal pregnancy and how many had subsequent molar pregnancies, in subsequent treatment cycles.RESULTS:
Between 68 and 76 molar pregnancies occurred within this period using ART (n = 274,655). The incidence of molar pregnancy using fresh intracytoplasmic sperm injection (ICSI) (1/4302) and fresh in vitro fertilisation (IVF) (1/4333) was similar. The risk of recurrence of molar pregnancy following a previous molar was higher following ART compared to spontaneous conceptions.CONCLUSION:
The use of ICSI should be protective against triploidy; however, the retrospective data suggests that molar pregnancy is not eliminated with the use of ART. It is pertinent to continue to record this data, through the gestational trophoblastic disease centres, in order to ensure no further increase in incidence, appropriate follow-up, and transparency in communication.Key words
Full text:
1
Database:
MEDLINE
Main subject:
Hydatidiform Mole
/
Chorionic Villi
/
Reproductive Techniques, Assisted
/
Gestational Trophoblastic Disease
Type of study:
Observational_studies
/
Risk_factors_studies
Limits:
Adult
/
Female
/
Humans
/
Male
/
Pregnancy
Language:
En
Journal:
J Assist Reprod Genet
Journal subject:
GENETICA
/
MEDICINA REPRODUTIVA
Year:
2019
Type:
Article
Affiliation country:
United kingdom