Functional characterization for polymorphic organic anion transporting polypeptides (OATP/SLCO1B1, 1B3, 2B1) of monkeys recombinantly expressed with various OATP probes.

Takahashi, Tsuyoshi; Uno, Yasuhiro; Yamazaki, Hiroshi; Kume, Toshiyuki

Takahashi, Tsuyoshi; Uno, Yasuhiro; Yamazaki, Hiroshi; Kume, Toshiyuki.

Affiliation

Takahashi T; Mitsubishi Tanabe Pharma Corporation, Toda, Saitama, 335-8505, Japan.
Uno Y; Shin Nippon Biomedical Laboratories, Ltd., Kainan, Wakayama, 642-0017, Japan.
Yamazaki H; Showa Pharmaceutical University, Machida, Tokyo, 194-8543, Japan.
Kume T; Mitsubishi Tanabe Pharma Corporation, Toda, Saitama, 335-8505, Japan.

Biopharm Drug Dispos ; 40(2): 62-69, 2019 Feb.

Article in En | MEDLINE | ID: mdl-30652318

Subject(s)

Organic Anion Transporters/metabolism; Quinolines/metabolism; Recombinant Proteins/metabolism; Telmisartan/metabolism; Animals; Drug Interactions; HEK293 Cells; Humans; Liver-Specific Organic Anion Transporter 1/genetics; Liver-Specific Organic Anion Transporter 1/metabolism; Macaca fascicularis; Macaca mulatta; Organic Anion Transporters/genetics; Plasmids; Pravastatin/metabolism; Recombinant Proteins/genetics; Rosuvastatin Calcium/metabolism; Solute Carrier Organic Anion Transporter Family Member 1B3/genetics; Solute Carrier Organic Anion Transporter Family Member 1B3/metabolism; Substrate Specificity

Key words

genetic polymorphisms; monkey OATP; pitavastatin; telmisartan

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Full text: 1 Database: MEDLINE Main subject: Quinolines / Recombinant Proteins / Organic Anion Transporters / Telmisartan Type of study: Guideline Limits: Animals / Humans Language: En Journal: Biopharm Drug Dispos Year: 2019 Type: Article Affiliation country: Japan

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