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Baicalin mitigates cognitive impairment and protects neurons from microglia-mediated neuroinflammation via suppressing NLRP3 inflammasomes and TLR4/NF-κB signaling pathway.
Jin, Xin; Liu, Ming-Yan; Zhang, Dong-Fang; Zhong, Xin; Du, Ke; Qian, Ping; Yao, Wei-Fan; Gao, Hua; Wei, Min-Jie.
Affiliation
  • Jin X; Department of Pharmacognosy, School of Pharmacy, China Medical University, Shenyang, China.
  • Liu MY; Department of Pharmacology, School of Pharmacy, China Medical University, Shenyang, China.
  • Zhang DF; Department of Pharmacognosy, School of Pharmacy, China Medical University, Shenyang, China.
  • Zhong X; Department of Pharmacology, School of Pharmacy, China Medical University, Shenyang, China.
  • Du K; Department of Pharmacology, School of Pharmacy, China Medical University, Shenyang, China.
  • Qian P; Department of Pharmacognosy, School of Pharmacy, China Medical University, Shenyang, China.
  • Yao WF; Department of Pharmacology, School of Pharmacy, China Medical University, Shenyang, China.
  • Gao H; Division of Pharmacology Laboratory, National Institutes for Food and Drug Control, Beijing, China.
  • Wei MJ; Department of Pharmacology, School of Pharmacy, China Medical University, Shenyang, China.
CNS Neurosci Ther ; 25(5): 575-590, 2019 05.
Article in En | MEDLINE | ID: mdl-30676698
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Full text: 1 Database: MEDLINE Main subject: Flavonoids / Anti-Inflammatory Agents, Non-Steroidal / Microglia / Nootropic Agents / Cognitive Dysfunction / Neurons Type of study: Clinical_trials Limits: Animals / Humans Language: En Journal: CNS Neurosci Ther Journal subject: NEUROLOGIA / TERAPEUTICA Year: 2019 Type: Article Affiliation country: China
Fulltext
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Full text: 1 Database: MEDLINE Main subject: Flavonoids / Anti-Inflammatory Agents, Non-Steroidal / Microglia / Nootropic Agents / Cognitive Dysfunction / Neurons Type of study: Clinical_trials Limits: Animals / Humans Language: En Journal: CNS Neurosci Ther Journal subject: NEUROLOGIA / TERAPEUTICA Year: 2019 Type: Article Affiliation country: China