An integrative systems approach identifies novel candidates in Marfan syndrome-related pathophysiology.

Bhushan, Raghu; Altinbas, Lukas; Jäger, Marten; Zaradzki, Marcin; Lehmann, Daniel; Timmermann, Bernd; Clayton, Nicholas P; Zhu, Yunxiang; Kallenbach, Klaus; Kararigas, Georgios; Robinson, Peter N

Bhushan, Raghu; Altinbas, Lukas; Jäger, Marten; Zaradzki, Marcin; Lehmann, Daniel; Timmermann, Bernd; Clayton, Nicholas P; Zhu, Yunxiang; Kallenbach, Klaus; Kararigas, Georgios; Robinson, Peter N.

Affiliation

Bhushan R; Charité University Hospital, Berlin, Germany.
Altinbas L; Yenepoya Research Centre, Yenepoya (Deemed to be University), Deralakatte, Mangalore, India.
Jäger M; Charité University Hospital, Berlin, Germany.
Zaradzki M; Charité University Hospital, Berlin, Germany.
Lehmann D; Berlin Institute of Health (BIH) Core Genomics Facility, Charité, University Medical Center, Berlin, Germany.
Timmermann B; Department of Cardiac Surgery, University Hospital Heidelberg, Heidelberg, Germany.
Clayton NP; Charité University Hospital, Berlin, Germany.
Zhu Y; Max Planck Institute for Molecular Genetics, Berlin, Germany.
Kallenbach K; Sanofi Genzyme, Framingham, Massachusetts.
Kararigas G; Sanofi Genzyme, Framingham, Massachusetts.
Robinson PN; Department of Cardiac Surgery, University Hospital Heidelberg, Heidelberg, Germany.

J Cell Mol Med ; 23(4): 2526-2535, 2019 04.

Article in En | MEDLINE | ID: mdl-30677223

Subject(s)

Aorta, Thoracic/metabolism; Carrier Proteins/genetics; Extracellular Matrix Proteins/genetics; Fibrillin-1/genetics; Glycoproteins/genetics; Insulin-Like Growth Factor Binding Protein 2/genetics; Marfan Syndrome/genetics; Osteopontin/genetics; Animals; Aorta, Thoracic/physiopathology; Carrier Proteins/metabolism; Chemokine CCL8/genetics; Chemokine CCL8/metabolism; Desmoplakins/genetics; Desmoplakins/metabolism; Disease Models, Animal; Extracellular Matrix Proteins/metabolism; Fibrillin-1/deficiency; Gene Expression Regulation; Gene Ontology; Glycoproteins/metabolism; Humans; Insulin-Like Growth Factor Binding Protein 2/metabolism; Marfan Syndrome/metabolism; Marfan Syndrome/physiopathology; Mice; Mice, Transgenic; Molecular Sequence Annotation; Myosin-Light-Chain Kinase/genetics; Myosin-Light-Chain Kinase/metabolism; Osteopontin/metabolism; RNA, Long Noncoding/genetics; RNA, Long Noncoding/metabolism; Signal Transduction; Smad2 Protein/genetics; Smad2 Protein/metabolism; Systems Biology/methods; eIF-2 Kinase/genetics; eIF-2 Kinase/metabolism

Key words

Chemokine signalling; Igfbp2 signalling; Marfan syndrome; Mfap4; RNA-sequencing; Spp1; TGF-beta signalling; Transcriptomics; mgR/mgR

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Full text: 1 Database: MEDLINE Main subject: Aorta, Thoracic / Glycoproteins / Carrier Proteins / Extracellular Matrix Proteins / Insulin-Like Growth Factor Binding Protein 2 / Osteopontin / Fibrillin-1 / Marfan Syndrome Type of study: Prognostic_studies Language: En Journal: J Cell Mol Med Journal subject: BIOLOGIA MOLECULAR Year: 2019 Type: Article Affiliation country: Germany

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