Predicting Cytotoxicity and Enzymatic Activity of Diverse Chemicals Using Goldfish Scale Tissue and Topminnow Hepatoma Cell Line-based Data.

Kahraman, Elif Nagihan; Saçan, Melek Türker

Kahraman, Elif Nagihan; Saçan, Melek Türker.

Affiliation

Kahraman EN; Ecotoxicology and Chemometrics Laboratory, Institute of Environmental Sciences, Bogazici University, Besiktas/Istanbul, Turkey.
Saçan MT; Ecotoxicology and Chemometrics Laboratory, Institute of Environmental Sciences, Bogazici University, Besiktas/Istanbul, Turkey.

Mol Inform ; 38(8-9): e1800127, 2019 08.

Article in En | MEDLINE | ID: mdl-30730112

Subject(s)

Antineoplastic Agents/pharmacology; Carcinoma, Hepatocellular/drug therapy; Enzyme Inhibitors/pharmacology; Liver Neoplasms/drug therapy; Quantitative Structure-Activity Relationship; Animals; Antineoplastic Agents/chemistry; Carcinoma, Hepatocellular/pathology; Cell Line, Tumor; Cell Proliferation/drug effects; Cytochrome P-450 CYP1A1/antagonists & inhibitors; Cytochrome P-450 CYP1A1/metabolism; Enzyme Inhibitors/chemistry; Fundulidae; Goldfish; Liver Neoplasms/pathology; Neutral Red/chemistry; Neutral Red/pharmacology; Phenazines/chemistry; Phenazines/pharmacology

Key words

EROD activity; QSTR; cytotoxicity; fish cell-line; inâvitro testing

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Full text: 1 Database: MEDLINE Main subject: Carcinoma, Hepatocellular / Quantitative Structure-Activity Relationship / Enzyme Inhibitors / Liver Neoplasms / Antineoplastic Agents Type of study: Prognostic_studies / Risk_factors_studies Limits: Animals Language: En Journal: Mol Inform Year: 2019 Type: Article Affiliation country: Turkey

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