Statistical assessment and visualization of synergies for large-scale sparse drug combination datasets.

Amzallag, Arnaud; Ramaswamy, Sridhar; Benes, Cyril H

Amzallag, Arnaud; Ramaswamy, Sridhar; Benes, Cyril H.

Affiliation

Amzallag A; The Center of Cancer Research, Massachusetts General Hospital, 149 13th Street, Charlestown, MA, 02129, USA. arnaud.amzallag@gmail.com.
Ramaswamy S; Harvard Medical School, Boston, MA, USA. arnaud.amzallag@gmail.com.
Benes CH; Broad Institute of Harvard and MIT, Cambridge, MA, USA. arnaud.amzallag@gmail.com.

BMC Bioinformatics ; 20(1): 83, 2019 Feb 18.

Article in En | MEDLINE | ID: mdl-30777010

Subject(s)

Antineoplastic Combined Chemotherapy Protocols/pharmacology; Drug Evaluation, Preclinical/methods; Models, Statistical; Cell Line, Tumor; Computer Graphics; Datasets as Topic; Drug Synergism; Humans; Linear Models

Key words

Bliss independence; Cancer cell lines; Cancer therapy; Drug combination; High-throughput screen; Melanoma; Statistical modeling; Synergy; Visualization

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Full text: 1 Database: MEDLINE Main subject: Antineoplastic Combined Chemotherapy Protocols / Models, Statistical / Drug Evaluation, Preclinical Type of study: Prognostic_studies / Risk_factors_studies Limits: Humans Language: En Journal: BMC Bioinformatics Journal subject: INFORMATICA MEDICA Year: 2019 Type: Article Affiliation country: United States

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