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An ROS-responsive and self-accelerating drug release nanoplatform for overcoming multidrug resistance.
Lv, Xueming; Zhu, Yiyong; Ghandehari, Hamidreza; Yu, Ao; Wang, Yongjian.
Affiliation
  • Lv X; Key Laboratory of Bioactive Materials, Ministry of Education, College of Life Sciences, Nankai University, Tianjin 300071, China. yongjian_wang@nankai.edu.cn.
Chem Commun (Camb) ; 55(23): 3383-3386, 2019 Mar 14.
Article in En | MEDLINE | ID: mdl-30821310
An 'on-demand' drug release and ROS-responsive nanoparticle was prepared by chemically conjugating hydrophobic α-tocopheryl succinate to hydrophilic poly(ethylene glycol) via a thioketal linker. This nanoparticle encapsulated with doxorubicin and α-tocopheryl succinate exhibited remarkable efficiency in reversing multidrug resistance both in vitro and in vivo.
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Full text: 1 Database: MEDLINE Main subject: Drug Carriers / Doxorubicin / Reactive Oxygen Species / Drug Resistance, Neoplasm / Nanoparticles / Antibiotics, Antineoplastic Limits: Animals / Humans Language: En Journal: Chem Commun (Camb) Journal subject: QUIMICA Year: 2019 Type: Article Affiliation country: China
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Full text: 1 Database: MEDLINE Main subject: Drug Carriers / Doxorubicin / Reactive Oxygen Species / Drug Resistance, Neoplasm / Nanoparticles / Antibiotics, Antineoplastic Limits: Animals / Humans Language: En Journal: Chem Commun (Camb) Journal subject: QUIMICA Year: 2019 Type: Article Affiliation country: China