Combined Deep Brain Stimulation of Subthalamic Nucleus and Ventral Intermediate Thalamic Nucleus in Tremor-Dominant Parkinson's Disease Using a Parietal Approach.
Neuromodulation
; 22(4): 493-502, 2019 Jun.
Article
in En
| MEDLINE
| ID: mdl-30889314
ABSTRACT
OBJECTIVES:
Despite its efficacy in tremor-suppression, the ventral intermediate thalamic (VIM) nucleus has largely been neglected in deep brain stimulation (DBS) for tremor-dominant Parkinson's disease (tdPD). The employment of a parietal approach, however, allows stimulation of VIM and subthalamic nucleus (STN) using one trajectory only and thus constitutes a promising alternative to existing strategies. In the present study, we investigate safety and efficacy of combined lead implantation and stimulation of STN and VIM using a parietal approach. MATERIALS ANDMETHODS:
Retrospective analysis of five patients with tdPD was performed who underwent DBS using a parietal approach. Changes in symptom severity, disease-specific health-related quality of life and l-dopa equivalent doses (LED) were evaluated over a total time course of 12 months.RESULTS:
DBS within both targets yielded significant improvement of parkinsonian symptoms (median 40.0%, p = 0.04) in the first 6 months of continuous stimulation and remained stable thereafter (median improvement at 12 months 43.2%, p = 0.07). Sustained improvement of tremor (median at 6 months 100.0%, p = 0.04; median at 12 months 83.3%, p = 0.04) and quality of life scores (median at 6 months 29.8%, p = 0.04; median at 12 months 32.6%, p = 0.04) was noted throughout the follow-up period. No significant change of LEDs was observed by the end of follow-up (median decrease 2.2%, p = 0.89).CONCLUSIONS:
Simultaneous DBS of VIM and STN using one trajectory is safe, yielding good control of parkinsonian tremors. Further studies, however, are necessary to determine whether a parietal trajectory affords better control over tremor symptoms than established strategies and hence justifies the potential risks associated with the alternative approach.Key words
Full text:
1
Database:
MEDLINE
Main subject:
Parietal Lobe
/
Parkinson Disease
/
Tremor
/
Subthalamic Nucleus
/
Ventral Thalamic Nuclei
/
Deep Brain Stimulation
Type of study:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Neuromodulation
Year:
2019
Type:
Article
Affiliation country:
Germany