Kujigamberoic acid A, a carboxylic acid derivative of kujigamberol, has potent inhibitory activity against the degranulation of RBL-2H3 cells.
Biosci Biotechnol Biochem
; 83(7): 1193-1196, 2019 Jul.
Article
in En
| MEDLINE
| ID: mdl-30917761
ABSTRACT
The aldehyde and carboxylic acid derivatives of kujigamberol were synthesized using pyridinium dichromate (PDC). The carboxylic acid derivative exhibited lower cytotoxicity and inhibited the degranulation of rat basophilic leukemia-2H3 (RBL-2H3) cells stimulated by thapsigargin more than kujigamberol. The carboxylic acid derivative was detected and isolated from the methanol extract of Kuji amber (MEKA) by the modified isolation procedure. Thus, it has been named as kujigamberoic acid A.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Cell Degranulation
/
Diterpenes
/
Antineoplastic Agents
Limits:
Animals
Language:
En
Journal:
Biosci Biotechnol Biochem
Journal subject:
BIOQUIMICA
/
BIOTECNOLOGIA
Year:
2019
Type:
Article
Affiliation country:
Japan