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Diphenyl ether derivatives occupy the expanded binding site of cyclohexanedione compounds at the colchicine site in tubulin by movement of the αT5 loop.
Bueno, Oskia; Gargantilla, Marta; Estévez-Gallego, Juan; Martins, Solange; Díaz, J Fernando; Camarasa, María-José; Liekens, Sandra; Pérez-Pérez, María-Jesús; Priego, Eva-María.
Affiliation
  • Bueno O; Instituto de Química Médica (IQM, CSIC), Juan de la Cierva 3, 28006, Madrid, Spain.
  • Gargantilla M; Instituto de Química Médica (IQM, CSIC), Juan de la Cierva 3, 28006, Madrid, Spain.
  • Estévez-Gallego J; Centro de Investigaciones Biológicas (CIB,CSIC), Ramiro de Maeztu 9, 28040, Madrid, Spain.
  • Martins S; Rega Institute for Medical Research, KU Leuven, Herestraat 49, B-3000, Leuven, Belgium.
  • Díaz JF; Centro de Investigaciones Biológicas (CIB,CSIC), Ramiro de Maeztu 9, 28040, Madrid, Spain.
  • Camarasa MJ; Instituto de Química Médica (IQM, CSIC), Juan de la Cierva 3, 28006, Madrid, Spain.
  • Liekens S; Rega Institute for Medical Research, KU Leuven, Herestraat 49, B-3000, Leuven, Belgium.
  • Pérez-Pérez MJ; Instituto de Química Médica (IQM, CSIC), Juan de la Cierva 3, 28006, Madrid, Spain.
  • Priego EM; Instituto de Química Médica (IQM, CSIC), Juan de la Cierva 3, 28006, Madrid, Spain. Electronic address: empriego@iqm.csic.es.
Eur J Med Chem ; 171: 195-208, 2019 Jun 01.
Article in En | MEDLINE | ID: mdl-30921759
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Full text: 1 Database: MEDLINE Main subject: Phenyl Ethers / Tubulin / Colchicine / Cyclohexanones / Antineoplastic Agents Limits: Humans Language: En Journal: Eur J Med Chem Year: 2019 Type: Article Affiliation country: Spain
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Full text: 1 Database: MEDLINE Main subject: Phenyl Ethers / Tubulin / Colchicine / Cyclohexanones / Antineoplastic Agents Limits: Humans Language: En Journal: Eur J Med Chem Year: 2019 Type: Article Affiliation country: Spain