Fungal Keratitis Caused by Colletotrichum dematium: Case Study and Review.
Mycopathologia
; 184(3): 441-453, 2019 Jun.
Article
in En
| MEDLINE
| ID: mdl-30949880
ABSTRACT
Colletotrichum species are known as important pathogens of plants with an impact on crop production. Some of these species are also known as a cause of rare ophthalmic infections in humans. A case of keratitis caused by Colletotrichum dematium after corneal trauma in a 56-year-old woman is presented. Infection was diagnosed based on positive microscopy and culture. The fungal isolate was identified by morphological characteristics and DNA sequencing of the ITS rDNA region, ß-tubulin (tub2) and glyceraldehyde-3-phosphate dehydrogenase (gapdh) genes. The patient responded well to topical therapy with amphotericin B combined with intravenous amphotericin B but improvement was associated with the corneal collagen cross-linking. The review of the literature revealed another 13 cases of C. dematium keratitis, all but one patient having at least one keratitis risk factor in their history. Almost all patients (n = 12) were treated with topical polyene antibiotics (natamycin or amphotericin B), improvement and cure were achieved in eight of them.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Eye Injuries
/
Colletotrichum
/
Keratitis
/
Mycoses
Type of study:
Diagnostic_studies
/
Prognostic_studies
/
Risk_factors_studies
/
Systematic_reviews
Limits:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Mycopathologia
Year:
2019
Type:
Article
Affiliation country:
Czech Republic