Estrogen regulation of cardiac cAMP-L-type Ca<sup>2+</sup> channel pathway modulates sex differences in basal contraction and responses to ß<sub>2</sub>AR-mediated stress in left ventricular apical myocytes.

Machuki, Jeremiah Ong'achwa; Zhang, Hong-Yuan; Geng, Juan; Fu, Lu; Adzika, Gabriel Komla; Wu, Lijuan; Shang, Wenkang; Wu, Jinxia; Kexue, Li; Zhao, Zhiwei; Sun, Hong

Estrogen regulation of cardiac cAMP-L-type Ca²⁺ channel pathway modulates sex differences in basal contraction and responses to ß₂AR-mediated stress in left ventricular apical myocytes.

Machuki, Jeremiah Ong'achwa; Zhang, Hong-Yuan; Geng, Juan; Fu, Lu; Adzika, Gabriel Komla; Wu, Lijuan; Shang, Wenkang; Wu, Jinxia; Kexue, Li; Zhao, Zhiwei; Sun, Hong.

Affiliation

Machuki JO; Physiology Department, Xuzhou Medical University, Xuzhou, 221004, Jiangsu, China.
Zhang HY; Physiology Department, Xuzhou Medical University, Xuzhou, 221004, Jiangsu, China.
Geng J; Institute of Cardiovascular Disease Research, Xuzhou Medical University, Xuzhou, 221002, China.
Fu L; Physiology Department, Xuzhou Medical University, Xuzhou, 221004, Jiangsu, China.
Adzika GK; Institute of Cardiovascular Disease Research, Xuzhou Medical University, Xuzhou, 221002, China.
Wu L; Physiology Department, Xuzhou Medical University, Xuzhou, 221004, Jiangsu, China.
Shang W; Physiology Department, Xuzhou Medical University, Xuzhou, 221004, Jiangsu, China.
Wu J; Physiology Department, Xuzhou Medical University, Xuzhou, 221004, Jiangsu, China.
Kexue L; Institute of Cardiovascular Disease Research, Xuzhou Medical University, Xuzhou, 221002, China.
Zhao Z; Institute of Cardiovascular Disease Research, Xuzhou Medical University, Xuzhou, 221002, China.
Sun H; Physiology Department, Xuzhou Medical University, Xuzhou, 221004, Jiangsu, China.

Cell Commun Signal ; 17(1): 34, 2019 04 15.

Article in En | MEDLINE | ID: mdl-30987657

Subject(s)

Calcium Channels, L-Type/metabolism; Cyclic AMP/metabolism; Estradiol/physiology; Myocardial Contraction/physiology; Myocytes, Cardiac/physiology; Receptors, Adrenergic, beta-2/metabolism; Sex Characteristics; Ventricular Function, Left/physiology; Animals; Calcium Channels, T-Type/metabolism; Calcium Signaling; Cardiotonic Agents/pharmacology; Cyclic Nucleotide Phosphodiesterases, Type 3/metabolism; Cyclic Nucleotide Phosphodiesterases, Type 4/metabolism; Estradiol/pharmacology; Female; Gene Expression Regulation; Male; Mice; Myocardial Contraction/drug effects; Myocytes, Cardiac/drug effects; Receptors, Adrenergic, beta-1/metabolism; Receptors, Estrogen/metabolism; Receptors, G-Protein-Coupled/agonists; Receptors, G-Protein-Coupled/metabolism; Ventricular Function, Left/drug effects

Key words

17ß-estradiol; Ca2+ transients; Cardiac stress; L-type Ca2+ channel; Phosphodiesterase; Sex differences in contractility

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google

Full text: 1 Database: MEDLINE Main subject: Ventricular Function, Left / Sex Characteristics / Receptors, Adrenergic, beta-2 / Cyclic AMP / Calcium Channels, L-Type / Myocytes, Cardiac / Estradiol / Myocardial Contraction Limits: Animals Language: En Journal: Cell Commun Signal Year: 2019 Type: Article Affiliation country: China

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google