Limits to Compensatory Mutations: Insights from Temperature-Sensitive Alleles.

Tomala, Katarzyna; Zrebiec, Piotr; Hartl, Daniel L

Tomala, Katarzyna; Zrebiec, Piotr; Hartl, Daniel L.

Affiliation

Tomala K; Institute of Environmental Sciences, Faculty of Biology, Jagiellonian University, Krakow, Poland.
Zrebiec P; Institute of Environmental Sciences, Faculty of Biology, Jagiellonian University, Krakow, Poland.
Hartl DL; Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA.

Mol Biol Evol ; 36(9): 1874-1883, 2019 09 01.

Article in En | MEDLINE | ID: mdl-31058959

Subject(s)

Mutation; Saccharomyces cerevisiae Proteins/genetics; Alleles; Amino Acid Sequence; Conserved Sequence; Orotidine-5'-Phosphate Decarboxylase/genetics; Saccharomyces cerevisiae; Structure-Activity Relationship; Temperature

Key words

Ura3; additivity; compensatory mutations; epistasis; protein stability

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Full text: 1 Database: MEDLINE Main subject: Saccharomyces cerevisiae Proteins / Mutation Type of study: Diagnostic_studies Language: En Journal: Mol Biol Evol Journal subject: BIOLOGIA MOLECULAR Year: 2019 Type: Article Affiliation country: Poland

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