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Inhibiting pathologically active ADAM10 rescues synaptic and cognitive decline in Huntington's disease.
Vezzoli, Elena; Caron, Ilaria; Talpo, Francesca; Besusso, Dario; Conforti, Paola; Battaglia, Elisa; Sogne, Elisa; Falqui, Andrea; Petricca, Lara; Verani, Margherita; Martufi, Paola; Caricasole, Andrea; Bresciani, Alberto; Cecchetti, Ottavia; Rivetti di Val Cervo, Pia; Sancini, Giulio; Riess, Olaf; Nguyen, Hoa; Seipold, Lisa; Saftig, Paul; Biella, Gerardo; Cattaneo, Elena; Zuccato, Chiara.
Affiliation
  • Vezzoli E; Department of Biosciences, University of Milan, Milan, Italy.
  • Caron I; Istituto Nazionale di Genetica Molecolare "Romeo ed Enrica Invernizzi," Milan, Italy.
  • Talpo F; Department of Biosciences, University of Milan, Milan, Italy.
  • Besusso D; Istituto Nazionale di Genetica Molecolare "Romeo ed Enrica Invernizzi," Milan, Italy.
  • Conforti P; Department of Biology and Biotechnologies, University of Pavia, Pavia, Italy.
  • Battaglia E; Department of Biosciences, University of Milan, Milan, Italy.
  • Sogne E; Istituto Nazionale di Genetica Molecolare "Romeo ed Enrica Invernizzi," Milan, Italy.
  • Falqui A; Department of Biosciences, University of Milan, Milan, Italy.
  • Petricca L; Istituto Nazionale di Genetica Molecolare "Romeo ed Enrica Invernizzi," Milan, Italy.
  • Verani M; Department of Biosciences, University of Milan, Milan, Italy.
  • Martufi P; Istituto Nazionale di Genetica Molecolare "Romeo ed Enrica Invernizzi," Milan, Italy.
  • Caricasole A; King Abdullah University of Science and Technology (KAUST), Biological and Environmental Science & Engineering (BESE) Division, NABLA Lab, Thuwal, Saudi Arabia.
  • Bresciani A; King Abdullah University of Science and Technology (KAUST), Biological and Environmental Science & Engineering (BESE) Division, NABLA Lab, Thuwal, Saudi Arabia.
  • Cecchetti O; IRBM Science Park SpA, Pomezia, Italy.
  • Rivetti di Val Cervo P; IRBM Science Park SpA, Pomezia, Italy.
  • Sancini G; IRBM Science Park SpA, Pomezia, Italy.
  • Riess O; IRBM Science Park SpA, Pomezia, Italy.
  • Nguyen H; IRBM Science Park SpA, Pomezia, Italy.
  • Seipold L; IRBM Science Park SpA, Pomezia, Italy.
  • Saftig P; Department of Biosciences, University of Milan, Milan, Italy.
  • Biella G; Istituto Nazionale di Genetica Molecolare "Romeo ed Enrica Invernizzi," Milan, Italy.
  • Cattaneo E; School of Medicine and Surgery, Nanomedicine Center, Neuroscience Center, University of Milano-Bicocca, Monza, Italy.
  • Zuccato C; Institute of Medical Genetics and Applied Genomics, University of Tuebingen, Tuebingen, Germany.
J Clin Invest ; 129(6): 2390-2403, 2019 05 06.
Article in En | MEDLINE | ID: mdl-31063986
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Full text: 1 Database: MEDLINE Main subject: Huntington Disease / Amyloid Precursor Protein Secretases / Post-Synaptic Density / Cognitive Dysfunction / ADAM10 Protein / Membrane Proteins Limits: Adult / Aged / Animals / Female / Humans / Male / Middle aged Language: En Journal: J Clin Invest Year: 2019 Type: Article Affiliation country: Italy
Fulltext
Add to My VHL
Print
XML
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Full text: 1 Database: MEDLINE Main subject: Huntington Disease / Amyloid Precursor Protein Secretases / Post-Synaptic Density / Cognitive Dysfunction / ADAM10 Protein / Membrane Proteins Limits: Adult / Aged / Animals / Female / Humans / Male / Middle aged Language: En Journal: J Clin Invest Year: 2019 Type: Article Affiliation country: Italy