Fetal thrombocytopenia in pregnancies complicated by fetal anemia due to red-cell alloimmunization: cohort study and meta-analysis.
J Perinatol
; 39(7): 920-926, 2019 07.
Article
in En
| MEDLINE
| ID: mdl-31073147
ABSTRACT
OBJECTIVE:
To estimate the prevalence and characteristics of fetal thrombocytopenia at the time of percutaneous umbilical cord sampling (PUBS) in pregnancies complicated by alloimmunization and to conduct a systematic review on fetal thrombocytopenia in these pregnancies. STUDYDESIGN:
Retrospective cohort study of all patients undergoing PUBS at our institution from 2000-2017. Clinical data, including fetal platelet counts, were abstracted from the medical record and analyzed with routine statistical procedures. A systematic review and meta-analysis were also conducted according to standard procedures.RESULT:
At first procedure, prior to any transfusion, 13/36 fetuses (36%) had thrombocytopenia 11/36 (31%) had moderate thrombocytopenia and 2/36 (6%) had severe thrombocytopenia (14 patients had no platelet count at first procedure). The systematic review identified six studies, and the prevalence of fetal thrombocytopenia at the time of PUBS for alloimmunization was 18% (95% confidence interval 11%, 26%).CONCLUSION:
Thrombocytopenia is common and underappreciated in fetuses undergoing PUBS for alloimmunization.
Full text:
1
Database:
MEDLINE
Main subject:
Thrombocytopenia
/
Blood Group Incompatibility
/
Fetal Blood
/
Fetal Diseases
Type of study:
Diagnostic_studies
/
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
/
Systematic_reviews
Limits:
Female
/
Humans
/
Pregnancy
Language:
En
Journal:
J Perinatol
Journal subject:
PERINATOLOGIA
Year:
2019
Type:
Article
Affiliation country:
United States