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Release of paused RNA polymerase II at specific loci favors DNA double-strand-break formation and promotes cancer translocations.
Dellino, Gaetano Ivan; Palluzzi, Fernando; Chiariello, Andrea Maria; Piccioni, Rossana; Bianco, Simona; Furia, Laura; De Conti, Giulia; Bouwman, Britta A M; Melloni, Giorgio; Guido, Davide; Giacò, Luciano; Luzi, Lucilla; Cittaro, Davide; Faretta, Mario; Nicodemi, Mario; Crosetto, Nicola; Pelicci, Pier Giuseppe.
Affiliation
  • Dellino GI; Department of Experimental Oncology, IEO, European Institute of Oncology IRCCS, Milan, Italy. gaetano.dellino@ieo.it.
  • Palluzzi F; Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy. gaetano.dellino@ieo.it.
  • Chiariello AM; Department of Experimental Oncology, IEO, European Institute of Oncology IRCCS, Milan, Italy.
  • Piccioni R; Department of Brain and Behavioural Sciences, University of Pavia, Pavia, Italy.
  • Bianco S; Department of Physics, University of Naples Federico II, and INFN Complesso di Monte Sant'Angelo, Naples, Italy.
  • Furia L; Department of Experimental Oncology, IEO, European Institute of Oncology IRCCS, Milan, Italy.
  • De Conti G; Department of Physics, University of Naples Federico II, and INFN Complesso di Monte Sant'Angelo, Naples, Italy.
  • Bouwman BAM; Department of Experimental Oncology, IEO, European Institute of Oncology IRCCS, Milan, Italy.
  • Melloni G; Department of Experimental Oncology, IEO, European Institute of Oncology IRCCS, Milan, Italy.
  • Guido D; Science for Life Laboratory, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.
  • Giacò L; Department of Experimental Oncology, IEO, European Institute of Oncology IRCCS, Milan, Italy.
  • Luzi L; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.
  • Cittaro D; Neurology, Public Health and Disability Unit, Foundation IRCCS Neurological Institute Carlo Besta, Milan, Italy.
  • Faretta M; Department of Experimental Oncology, IEO, European Institute of Oncology IRCCS, Milan, Italy.
  • Nicodemi M; Department of Experimental Oncology, IEO, European Institute of Oncology IRCCS, Milan, Italy.
  • Crosetto N; Center for Translational Genomics and Bioinformatics, IRCCS San Raffaele Hospital, Milan, Italy.
  • Pelicci PG; Department of Experimental Oncology, IEO, European Institute of Oncology IRCCS, Milan, Italy.
Nat Genet ; 51(6): 1011-1023, 2019 06.
Article in En | MEDLINE | ID: mdl-31110352
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Full text: 1 Database: MEDLINE Main subject: RNA Polymerase II / DNA Breaks, Double-Stranded / Genetic Loci / Neoplasms Type of study: Prognostic_studies Limits: Animals Language: En Journal: Nat Genet Journal subject: GENETICA MEDICA Year: 2019 Type: Article Affiliation country: Italy
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Full text: 1 Database: MEDLINE Main subject: RNA Polymerase II / DNA Breaks, Double-Stranded / Genetic Loci / Neoplasms Type of study: Prognostic_studies Limits: Animals Language: En Journal: Nat Genet Journal subject: GENETICA MEDICA Year: 2019 Type: Article Affiliation country: Italy