microRNA-96 promotes osteoblast differentiation and bone formation in ankylosing spondylitis mice through activating the Wnt signaling pathway by binding to SOST.

Ma, Shu; Wang, Dan-Dan; Ma, Cheng-Yuan; Zhang, Yan-Dong

Ma, Shu; Wang, Dan-Dan; Ma, Cheng-Yuan; Zhang, Yan-Dong.

Affiliation

Ma S; Department of Rheumatology, The First Hospital of Jilin University, Changchun, People's Republic of China.
Wang DD; Department of Neurology, The First Hospital of Jilin University, Changchun, People's Republic of China.
Ma CY; Department of Neurosurgery, The First Hospital of Jilin University, Changchun, People's Republic of China.
Zhang YD; Department of Rheumatology, The First Hospital of Jilin University, Changchun, People's Republic of China.

J Cell Biochem ; 120(9): 15429-15442, 2019 09.

Article in En | MEDLINE | ID: mdl-31111563

Subject(s)

Adaptor Proteins, Signal Transducing/genetics; Adaptor Proteins, Signal Transducing/metabolism; MicroRNAs/genetics; Osteoblasts/cytology; Spondylitis, Ankylosing/genetics; 3' Untranslated Regions; Animals; Cell Differentiation; Disease Models, Animal; Gene Expression Regulation; HEK293 Cells; Humans; Interleukin-10/metabolism; Interleukin-6/metabolism; Male; Mice; Osteoblasts/metabolism; Spondylitis, Ankylosing/metabolism; Tumor Necrosis Factor-alpha/metabolism; Wnt Signaling Pathway

Key words

Wnt signaling pathway; ankylosing spondylitis; bone formation; microRNA-96; osteoblast differentiation; sclerostin

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Full text: 1 Database: MEDLINE Main subject: Osteoblasts / Spondylitis, Ankylosing / MicroRNAs / Adaptor Proteins, Signal Transducing Type of study: Prognostic_studies Limits: Animals / Humans / Male Language: En Journal: J Cell Biochem Year: 2019 Type: Article

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