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DNA repair enzymes ALKBH2, ALKBH3, and AlkB oxidize 5-methylcytosine to 5-hydroxymethylcytosine, 5-formylcytosine and 5-carboxylcytosine in vitro.
Bian, Ke; Lenz, Stefan A P; Tang, Qi; Chen, Fangyi; Qi, Rui; Jost, Marco; Drennan, Catherine L; Essigmann, John M; Wetmore, Stacey D; Li, Deyu.
Affiliation
  • Bian K; Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island, Kingston, RI 02881, USA.
  • Lenz SAP; Department of Chemistry and Biochemistry, University of Lethbridge, 4401 University Drive West, Lethbridge, Alberta T1K 3M4, Canada.
  • Tang Q; Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island, Kingston, RI 02881, USA.
  • Chen F; Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island, Kingston, RI 02881, USA.
  • Qi R; Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island, Kingston, RI 02881, USA.
  • Jost M; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
  • Drennan CL; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
  • Essigmann JM; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
  • Wetmore SD; Center for Environmental Health Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
  • Li D; Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Nucleic Acids Res ; 47(11): 5522-5529, 2019 06 20.
Article in En | MEDLINE | ID: mdl-31114894
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Full text: 1 Database: MEDLINE Main subject: Cytosine / 5-Methylcytosine / AlkB Enzymes / AlkB Homolog 2, Alpha-Ketoglutarate-Dependent Dioxygenase / AlkB Homolog 3, Alpha-Ketoglutarate-Dependent Dioxygenase Limits: Animals / Humans Language: En Journal: Nucleic Acids Res Year: 2019 Type: Article Affiliation country: United States
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Full text: 1 Database: MEDLINE Main subject: Cytosine / 5-Methylcytosine / AlkB Enzymes / AlkB Homolog 2, Alpha-Ketoglutarate-Dependent Dioxygenase / AlkB Homolog 3, Alpha-Ketoglutarate-Dependent Dioxygenase Limits: Animals / Humans Language: En Journal: Nucleic Acids Res Year: 2019 Type: Article Affiliation country: United States